Human T lymphocytes reactive with whole myelin recognize predominantly myelin basic protein.

Journal of Neuroimmunology
J Burns, K Littlefield

Abstract

Human T-cell lines and clones reactive with whole human myelin were isolated from three normal subjects by in vitro sensitization techniques. The CD4+ T-cell lines were maintained in long-term culture by periodic antigen restimulation with myelin and use of interleukin-2. Although myelin basic protein (MBP) represents only about 10% of the dry weight of myelin and the myelin-reactive T-cell populations were never exposed to purified MBP, each of the three cell lines responded to in vitro stimulation with both MBP and whole myelin. Seventeen of 18 T-cell clones derived from the myelin-reactive cell lines also responded to MBP. One myelin-reactive T-cell clone did not recognize MBP or the major myelin lipids but responded to delipidated myelin proteins suggesting that this clone recognized another myelin protein antigen. These results indicate that MBP is the predominant antigen in whole myelin recognized by human T cells under the culture conditions described. However, there is at least one additional protein antigen in myelin that is also immunogenic.

References

Jan 1, 1977·British Medical Bulletin·S C Knight
Feb 12, 1987·The New England Journal of Medicine·T HemachudhaP Phanuphak
Jun 1, 1987·Journal of the Neurological Sciences·J L TrotterJ D Scarpellini
Oct 1, 1973·Journal of Neurochemistry·W T Norton, S E Poduslo
Nov 1, 1971·Journal of Neurochemistry·S GreenfieldP Morell
Jan 1, 1984·Annals of the New York Academy of Sciences·R P LisakD H Silberberg
Nov 27, 1982·Lancet·J Gould
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A A IlyasR O Brady
Sep 11, 1980·The New England Journal of Medicine·N LatovE F Osserman
Apr 15, 1983·Cellular Immunology·J BurnsR P Lisak
Jan 1, 1960·The Journal of Experimental Medicine·P Y PATERSON
Jun 30, 1933·The Journal of Experimental Medicine·T M RiversG P Berry
Apr 30, 1935·The Journal of Experimental Medicine·T M Rivers, F F Schwentker

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.