PMID: 7545241Oct 1, 1995Paper

Human T-lymphotropic virus type 1 peptides in chimeric and multivalent constructs with promiscuous T-cell epitopes enhance immunogenicity and overcome genetic restriction

Journal of Virology
M D LairmorePravin T P Kaumaya

Abstract

Conventional strategies of viral peptide immunizations often elicit low-affinity antibody responses and have limited ability to elicit immune responses in outbred animals of diverse major histocompatibility (MHC) haplotypes. This genetically restricted T-cell-stimulatory activity of peptides is a serious obstacle to vaccine design. However, the use of promiscuous T-cell epitopes may circumvent this problem. Promiscuous T-cell epitopes from tetanus toxin (amino acids [aa] 580 to 599) and the measles virus F protein (aa 288 to 302) that bind to several isotypic and allotypic forms of human MHC class II molecules have been identified and have been used in highly immunogenic constructs to overcome haplotype-restricted immune responses. Chimeric and beta-template peptide constructs incorporating known human T-lymphotropic virus type 1 (HTLV-1) B- and T-cell epitopes from the surface envelope protein gp46 (SP2 [aa 86 to 107] and SP4a [aa 190 to 209]) and promiscuous T-cell peptides were synthesized, and their immunogenicities were evaluated in both rabbits and mouse strains of divergent haplotypes (C3H/HeJ [H-2k], C57BL/6 [H-2b], and BALB/c [H-2d]). In addition, peptide preparations were structurally characterized by analytical high-...Continue Reading

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Citations

Apr 12, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Naveen K DakappagariPravin T P Kaumaya
Mar 11, 2004·The Journal of Peptide Research : Official Journal of the American Peptide Society·R SundaramP T P Kaumaya
May 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joan T GarrettPravin T P Kaumaya
Apr 30, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Karla Ramírez-GualitoStefan Berger
Feb 1, 2016·Chemical Science·Mariusz Skwarczynski, Istvan Toth
Nov 9, 2004·Chemistry : a European Journal·Gaëlle-Anne CremerAgnès Delmas
May 24, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kevin Chu FoyPravin T P Kaumaya
Jun 4, 2013·Journal of Peptide Science : an Official Publication of the European Peptide Society·Monique RichterDavid Singer
Sep 22, 1999·European Journal of Biochemistry·C DelmotteA Delmas
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SrinivasanP T Kaumaya
Apr 20, 2011·American Journal of Reproductive Immunology : AJRI·Satish K GuptaAmulya K Panda
Jan 1, 1996·Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association·R B Lal
Oct 18, 2002·Biopolymers·Roshni SundaramPravin T P Kaumaya
Mar 1, 2013·American Journal of Reproductive Immunology : AJRI·Neha GuptaSatish K Gupta
Mar 3, 2021·Journal of Biomolecular Structure & Dynamics·Hamid Reza JahantighKhadijeh Ahmadi
Jun 17, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroya KobayashiEsteban Celis
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Hiroya KobayashiEsteban Celis
Mar 12, 1998·International Journal of Cancer. Journal International Du Cancer·M P GrangeC Desgranges
Mar 8, 2011·Journal of Reproductive Immunology·Satish K GuptaV A Srinivasan

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