Human telomerase catalytic subunit gene re-expression is an early event in oral carcinogenesis

Histopathology
Bostjan LuzarNina Gale

Abstract

Detection of telomerase catalytic subunit (hTERT) mRNA has been used as a surrogate marker for estimation of telomerase activity. The exact role and timing of telomerase re-activation, a key enzyme implicated in cellular immortalization and transformation, in the multistep process of oral carcinogenesis is still unknown. The aim was to test the hypothesis that (i) quantitative rather than qualitative differences exist in the level of hTERT mRNA expression between normal oral mucosa, different grades of oral epithelial abnormalities and squamous cell carcinomas of the oral cavity, and that (ii) hTERT gene re-expression is an important, probably early event in oral carcinogenesis. The relative quantity of hTERT mRNA was analysed in 45 frozen oral epithelia representing different morphological stages of oral carcinogenesis classified according to the Ljubljana classification and in 37 oral squamous cell carcinomas, using a commercially available LightCycler Telo TAGGG hTERT Quantification kit. hTERT mRNA was not detected in normal or reactive hyperplastic oral epithelia, but was present in 43% of atypical hyperplasias (premalignant lesions), 60% of intraepithelial carcinomas and 68% of oral squamous cell carcinomas. Statistical an...Continue Reading

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Citations

Aug 28, 2010·Revue de stomatologie et de chirurgie maxillo-faciale·H Reychler, B Weynand
Aug 31, 2007·Biochimie·J Arturo Londoño-Vallejo
Jan 10, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·P ArenbergerJ Kremen
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Aug 10, 2016·Cancer Metastasis Reviews·Paolo Boscolo-RizzoAnita De Rossi
Sep 7, 2019·Pathology Oncology Research : POR·Lizbeth Raju KShwetha Nambiar
Jan 17, 2020·Journal of Oral and Maxillofacial Pathology : JOMFP·Namrata MishraVijay Kumar

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