Human Telomerase RNA: Telomerase Component or More?

Biomolecules
M P Rubtsova, O A Dontsova

Abstract

Telomerase is a ribonucleoprotein complex that maintains the lengths of telomeres. Most studies of telomerase function have focused on the involvement of telomerase activation in the immortalization of cancer cells and cellular rejuvenation. However, some studies demonstrated that the results do not meet expectations for telomerase action in telomere maintenance. Recent results give reason to think that major telomerase components-the reverse transcriptase protein subunit and telomerase RNA-may participate in many cellular processes, including the regulation of apoptosis and autophagy, cell survival, pro-proliferative effects, regulation of gene expression, and protection against oxidative stress. However, the difficulties faced by scientist when researching telomerase component functions often reduce confidence in the minor effects observed in experiments. In this review, we focus on the analysis of the functions of telomerase components (paying more attention to the telomerase RNA component), both as a complex and as independent components, providing effects that are not associated with telomerase activity and telomere length maintenance. Despite the fact that the data on alternative roles of telomerase components look illuso...Continue Reading

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Citations

Oct 15, 2020·Biomolecules·Petra Procházková Schrumpfová, Jiří Fajkus
Feb 9, 2021·Frontiers in Genetics·Alexander Vaiserman, Dmytro Krasnienkov
Dec 25, 2021·Frontiers in Cell and Developmental Biology·Viktoriia ShliapinaMaria Rubtsova

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Methods Mentioned

BETA
pull-down
PCR

Software Mentioned

BLAT

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