Human tissue kallikrein gene family: a rich source of novel disease biomarkers

Expert Review of Molecular Diagnostics
Eleftherios P Diamandis, George M Yousef

Abstract

The organization of the human tissue kallikrein gene family has now been fully elucidated. This family contains 15 genes encoding secreted serine proteases, which share significant homologies at both the DNA and amino acid level. Two members of the human kallikrein gene family, prostate-specific antigen and human kallikrein 2, have already found important clinical application as prostate cancer biomarkers. In this review, we examine the diagnostic and prognostic value of the 15 human kallikrein genes and proteins. It is clear that at least a few members show promise of becoming novel cancer and other disease biomarkers.

References

Oct 6, 1997·The Journal of Biological Chemistry·S P LittleE M Johnstone
Sep 28, 1998·The European Journal of Neuroscience·Y MomotaS Shiosaka
May 21, 1999·Archives of Dermatological Research·E Ekholm, T Egelrud
Apr 7, 2000·Breast Cancer Research and Treatment·M H Black, E P Diamandis
Apr 15, 2008·Trends in Endocrinology and Metabolism : TEM·E P Diamandis

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Citations

Feb 2, 2013·Cellular and Molecular Life Sciences : CMLS·John T HeikerAnnette G Beck-Sickinger
Sep 1, 2008·Head and Neck Pathology·Mark R DarlingEleftherios P Diamandis
Mar 14, 2003·Clinical Biochemistry·Lianna G KyriakopoulouEleftherios P Diamandis
Oct 19, 2002·Urology·George M YousefEleftherios P Diamandis
May 3, 2003·Breast Cancer Research and Treatment·George M YousefEleftherios P Diamandis
Nov 20, 2002·Biological Chemistry·George M Yousef, Eleftherios P Diamandis
Jun 28, 2006·Biological Chemistry·Constantina D PetrakiEleftherios P Diamandis
Dec 19, 2008·Biological Chemistry·Hyesook YoonMichael Blaber
Dec 18, 2012·Biological Chemistry·Hyesook YoonMichael Blaber
Aug 17, 2004·Critical Reviews in Clinical Laboratory Sciences·Judith A ClementsYing Dong
Apr 15, 2014·The Urologic Clinics of North America·Richard J Bryant, Hans Lilja
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Carla A BorgoñoDionyssios Katsaros
Jan 3, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vijay KumarSavita Yadav
Sep 16, 2004·Journal of Cellular Biochemistry·Joshua Kim, Gerhard A Coetzee
Aug 14, 2008·Protein Science : a Publication of the Protein Society·Hyesook YoonMichael Blaber
Nov 19, 2009·International Journal of Cancer. Journal International Du Cancer·Lara TerminiLuisa Lina Villa
May 30, 2006·Clinical Biochemistry·Raymond Lepage, Caroline Albert
Aug 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·George M YousefEleftherios P Diamandis
Jun 4, 2016·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Omer Gokhan DoluogluOner Odabas
Jul 1, 2004·Expert Review of Molecular Diagnostics·Daphne HesselsJ Alfred Witjes
Nov 16, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·M R DarlingE P Diamandis
Jun 10, 2018·Biological Chemistry·Carlos D FigueroaPamela Ehrenfeld
Aug 17, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·George M YousefEleftherios P Diamandis
Jan 8, 2004·British Journal of Cancer·G M YousefE P Diamandis
Sep 8, 2007·The Journal of Biological Chemistry·Hyesook YoonMichael Blaber
Jan 1, 2003·Clinical Chemistry·Tadaaki KishiEleftherios P Diamandis
Jul 16, 2005·Scandinavian Journal of Urology and Nephrology. Supplementum·Jack A SchalkenPeter Wiklund
Jul 14, 2020·Frontiers in Cellular Neuroscience·Cinthia MellaPamela Ehrenfeld
Aug 19, 2018·Head and Neck Pathology·Matthew D MorrisonMark R Darling

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