PMID: 9171097Jun 15, 1997Paper

Human transcription factors IIIC2 , IIIC1 and a novel component IIIC0 fulfil different aspects of DNA binding to various pol III genes

Nucleic Acids Research
S OettelKlaus H Seifart

Abstract

Human transcription factor IIIC2 interacts with the TFIIIA-5S DNA complex and forms a ternary TFIIIA/IIIC2-5S DNA complex. Formation of this complex does not preclude simultaneous binding of TFIIIC2to the B-box sequence of a second template. This suggests that the domain(s) or subunit(s) required for indirect recognition of the 5S promoter by TFIIIC2 are different from those necessary for direct binding of TFIIIC2 to B-box-containing pol III promoters. Whereas TFIIIC2 is only required for transcription of the 'classical' pol III genes, TFIIIC1 is generally required for transcription of all pol III genes, including that of the U6 gene. The activity of TFIIIC1 strongly enhances specific binding of basal pol III factors TFIIIA, TFIIIC2 and the PSE binding protein (PBP) to their cognate promoter elements and it acts independently of the corresponding termination regions. Moreover, we characterize an activity, TFIIIC0, purified from phosphocellulose fraction C, which shows strong DNase I protection of the termination region of several pol III genes and which is functionally and chromatographically distinct from TFIIIC1 and TFIIIC2.

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Citations

Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Thorsten BieberHans-Peter Elsasser
Jul 6, 2001·The Plant Journal : for Cell and Molecular Biology·P ArnaudJ M Deragon
Feb 24, 2000·Nucleic Acids Research·M R Paule, R J White
Sep 16, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Victoria V Lunyak, Michelle Atallah
Jun 23, 2001·Journal of Molecular Biology·E P Geiduschek, G A Kassavetis
Oct 5, 2010·Cell Cycle·Hélène Dumay-OdelotMartin Teichmann
Apr 6, 2007·The Journal of Biological Chemistry·Hélène Dumay-OdelotMartin Teichmann
Dec 14, 2001·The Journal of Biological Chemistry·Wolfgang MeissnerKlaus H Seifart
Jun 20, 1998·Molecular and Cellular Biology·N ManaudA Sentenac
Oct 17, 2002·Genes & Development·Laura Schramm, Nouria Hernandez

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