Human triploidy: relationship between parental origin of the additional haploid complement and development of partial hydatidiform mole

Annals of Human Genetics
P A JacobsC C Wilson

Abstract

One hundred and six triploids were ascertained during a study of 1500 consecutive spontaneous abortions. The mechanism of origin of the additional haploid complement was investigated by comparing parental and foetal cytogenetic heteromorphisms and a histopathological examination of each triploid was done in a subsequent blind study. The mechanism of origin of the additional haploid complement was found to be highly correlated with the development of partial hydatidiform mole and with gestational age. All 51 paternally derived triploids in which a pathologic diagnosis could be made were partial moles, whereas only 3 of 15 maternally derived triploids on which a diagnosis could be made were molar. The mean gestational age of the paternally derived triploids was 122 days while that of the maternally derived triploids was only 74 days. It was suggested that the development of partial mole was primarily associated with the presence of two paternal haploid chromosome complements, the association with relatively long gestational ages being a secondary one consequent upon retention of the molar placentae for many weeks after foetal demise.

References

Jul 1, 1978·Lancet·P A JacobsI M Newlands
Sep 15, 1979·Lancet·S D LawlerA E Szulman
Jan 15, 1977·American Journal of Obstetrics and Gynecology·P VassilakosT Kajii
Aug 18, 1977·Nature·T Kajii, K Ohama
Jul 15, 1978·American Journal of Obstetrics and Gynecology·A E Szulman, U Surti
Jul 1, 1978·Annals of Human Genetics·P A JacobsB Manuel
Sep 1, 1978·American Journal of Obstetrics and Gynecology·A E Szulman, U Surti
Sep 22, 1977·Human Genetics·J P FrynsH van den Berghe
Jan 1, 1975·Archiv für Gynäkologie·A SchinzelE Boltshauser
Feb 21, 1974·Humangenetik·E Niebuhr
Feb 1, 1982·Cancer Genetics and Cytogenetics·S D LawlerT J McElwain
Nov 1, 1982·Cancer Genetics and Cytogenetics·F HechtJ D Cohen
Aug 6, 1981·Nature·K OhamaK Hagiwara
Oct 1, 1980·Annals of Human Genetics·T HassoldP A Jacobs
Dec 12, 1964·Lancet·S MAKINOT FUKUSCHIMA

❮ Previous
Next ❯

Citations

Apr 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·H Bałakier, R F Casper
Oct 1, 1996·Journal of Assisted Reproduction and Genetics·Y IkedaT Ishimaru
Jan 1, 1985·Archives of Gynecology·R UlmerR A Pfeiffer
May 4, 2013·Journal of Assisted Reproduction and Genetics·Philip SavageRosemary A Fisher
Oct 16, 2012·Pathology Oncology Research : POR·Jean-Jacques CandelierPhilippe Coullin
Dec 2, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·F J Paradinas
Dec 1, 1996·Obstetrics and Gynecology·E JauniauxK H Nicolaides
Jul 1, 1992·Baillière's Clinical Endocrinology and Metabolism·H Enders
Dec 31, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·N J SebireE S Newlands
Jun 12, 2003·BJOG : an International Journal of Obstetrics and Gynaecology·B W L ThamB W Hancock
Nov 15, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Annie Nga-Yin Cheung
Nov 15, 2000·Clinical Genetics·D E McFadden, S Langlois
Sep 1, 1996·Archives of Environmental Health·M C HaT N Nguyen
Aug 22, 2013·Molecular Human Reproduction·L AndreasenL Sunde
Aug 5, 2000·The Australian & New Zealand Journal of Obstetrics & Gynaecology·F Rahimpanah, J Smoleniec
Mar 20, 1998·American Journal of Reproductive Immunology : AJRI·D K Kalousek
Jun 1, 1987·Journal of Clinical Pathology·J D HemmingC C Bird
Oct 21, 2005·Journal of Medical Genetics·D E McFadden, W P Robinson
Feb 1, 1984·Journal of Medical Genetics·J C LambertN Ayraud
Oct 1, 1987·Journal of Medical Genetics·L O VejerslevN Wake
Dec 1, 1991·Journal of Medical Genetics·P MerlobM Shohat
Jan 19, 2012·PloS One·Henriette PoatyAlain Bernheim
Jul 28, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Natalie BanetBrigitte M Ronnett
Jan 25, 2014·Journal of Assisted Reproduction and Genetics·Mette Warming JoergensenKirstine Kirkegaard
Sep 4, 2014·Annual Review of Genomics and Human Genetics·Patricia A Jacobs
Sep 15, 2012·Annual Review of Genetics·Christine M Disteche
Dec 1, 1990·American Journal of Reproductive Immunology : AJRI·S Takeuchi
Jan 1, 1997·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Y Zalel, R Dgani
May 10, 2013·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P M SavageM J Seckl
Nov 15, 2015·American Journal of Medical Genetics. Part a·Jennifer E PoseyAmy M Breman
Oct 1, 1984·American Journal of Obstetrics and Gynecology·D A Grimes
Jul 1, 1987·American Journal of Obstetrics and Gynecology·L O VejerslevN Walke
May 1, 1991·American Journal of Obstetrics and Gynecology·S D LawlerJ Dent
May 1, 1994·American Journal of Obstetrics and Gynecology·C C HsuP Braude

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