Human trophoblast invasion and spiral artery transformation: the role of PECAM-1 in normal pregnancy, preeclampsia, and fetal growth restriction

The American Journal of Pathology
F LyallS C Robson

Abstract

During early human pregnancy extravillous cytotrophoblasts invade the uterus and spiral arteries transforming them into large vessels of low resistance. Failure of trophoblast invasion and spiral artery transformation occurs in preeclampsia and fetal growth restriction (FGR); these processes are not well understood. Recent studies have suggested that cytotrophoblasts that invade spiral arteries mimic the endothelial cells they replace and express PECAM-1. It was also reported that in preeclampsia, cytotrophoblasts fail to express PECAM-1 and that failure to express endothelial cell adhesion molecules may account for failed trophoblast invasion. Despite the possible importance of adhesion molecules in trophoblast invasion, no study has systematically investigated the expression of PECAM-1 in the placental bed throughout the period of invasion, particularly in the myometrial segments where the key failure occurs. There are no studies on PECAM-1 expression in the placental bed in FGR. We have examined the expression of PECAM-1 in placental bed biopsies and placentas from 8 to 19 weeks of gestation and in the placenta and placental bed in the third trimester in cases of preeclampsia, FGR, and control pregnancies. PECAM-1 was expres...Continue Reading

References

Dec 1, 1976·British Journal of Obstetrics and Gynaecology·B L Sheppard, J Bonnar
Apr 1, 1991·The Journal of Cell Biology·C L LibrachS J Fisher
Jul 1, 1991·British Journal of Obstetrics and Gynaecology·R PijnenborgA van Assche
Nov 1, 1990·British Journal of Obstetrics and Gynaecology·M Z MichelR W Beard
Apr 13, 1990·Science·S KovatsR DeMars
Jul 1, 1987·British Journal of Obstetrics and Gynaecology·T Y KhongW B Robertson
Nov 15, 1973·American Journal of Obstetrics and Gynecology·F De WolfI Brosens
Apr 1, 1967·The Journal of Pathology and Bacteriology·I BrosensH G Dixon
Mar 1, 1993·The Journal of Clinical Investigation·Y ZhouS J Fisher
Oct 1, 1994·Immunology Today·H M DeLisserS M Albelda
Aug 1, 1994·British Journal of Obstetrics and Gynaecology·J W MeekinsA van Asshe
Jun 5, 1993·Lancet·J M Roberts, C W Redman
Aug 1, 1993·The Journal of Experimental Medicine·W A MullerD M Phillips
Jan 1, 1997·The Journal of Clinical Investigation·P J Newman
May 11, 1999·The American Journal of Pathology·F LyallS C Robson
Jan 8, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F LyallS C Robson

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Citations

Apr 5, 2007·Cell and Tissue Research·J PafilisK Charalabopoulos
Feb 10, 2007·Reproductive Biology and Endocrinology : RB&E·Laura LunghiFortunato Vesce
Jun 11, 2004·Cell Communication and Signaling : CCS·Twanda L ThirkillGordon C Douglas
Feb 19, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Marzena LaskowskaJan Oleszczuk
Feb 24, 2007·Vascular Health and Risk Management·Mitsuko FuruyaHiroshi Ishikura
Jul 20, 2007·Reproduction : the Official Journal of the Society for the Study of Fertility·J SenguptaD Ghosh
Jul 12, 2003·High Altitude Medicine & Biology·Stacy Zamudio
Jan 9, 2016·Cell Adhesion & Migration·Juneo F Silva, Rogéria Serakides
Dec 29, 2011·Clinical & Developmental Immunology·Chiara AgostinisRoberta Bulla
Feb 5, 2005·Seminars in Fetal & Neonatal Medicine·Vandana ChaddhaJohn Kingdom
Feb 9, 2018·Experimental Biology and Medicine·M L Martinez-FierroI Garza-Veloz
Dec 13, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paddy J SlatorDaniel C Alexander
Dec 4, 2017·Interdisciplinary Sciences, Computational Life Sciences·Surama BiswasSriyankar Acharyya
Jan 22, 2015·Arthritis & Rheumatology·Danieli AndradeJane E Salmon
Jan 31, 2013·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·S RobergeE Bujold
May 12, 2018·Reproduction : the Official Journal of the Society for the Study of Fertility·Stella LiongMartha Lappas
Jun 21, 2018·American Journal of Reproductive Immunology : AJRI·Kassem SharifYehuda Shoenfeld
Jul 27, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Fiona Lyall
Dec 23, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qin LiuYi Shen
Jan 26, 2006·Endocrine Reviews·Vanessa E MurphyVicki L Clifton
May 31, 2019·American Journal of Reproductive Immunology : AJRI·Fiorella Di NicuoloNicoletta Di Simone
Jan 17, 2020·American Journal of Reproductive Immunology : AJRI·Nicole S OlgunStephen S Leonard
Nov 16, 2019·Genesis : the Journal of Genetics and Development·Huiying ZhiPeter J Newman
Feb 13, 2020·Reproductive Sciences·Elizabeth T GreeleyChristine N Metz
Feb 25, 2009·The American Journal of Forensic Medicine and Pathology·Daniela MarchettiEzio Fulcheri
Oct 21, 2018·Reproductive Biology and Endocrinology : RB&E·Rachel C WestQuinton A Winger
Apr 14, 2016·The Journal of Pathology·Fu-Ju TianYi Lin
May 14, 2003·Wiener klinische Wochenschrift·Jeffrey C Livingston, Bryan D Maxwell
Jan 29, 2017·Human Reproduction·M BarjaktarovicR P Peeters
Feb 28, 2019·Stem Cells International·Manuel Varas-GodoySebastian E Illanes
Aug 10, 2018·Current Hypertension Reports·Linda G Kahn, Leonardo Trasande

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