Human Tubal-Derived Mesenchymal Stromal Cells Associated with Low Level Laser Therapy Significantly Reduces Cigarette Smoke-Induced COPD in C57BL/6 mice

PloS One
Jean Pierre Schatzmann PeronAna Paula Ligeiro de Oliveira

Abstract

Cigarette smoke-induced chronic obstructive pulmonary disease is a very debilitating disease, with a very high prevalence worldwide, which results in a expressive economic and social burden. Therefore, new therapeutic approaches to treat these patients are of unquestionable relevance. The use of mesenchymal stromal cells (MSCs) is an innovative and yet accessible approach for pulmonary acute and chronic diseases, mainly due to its important immunoregulatory, anti-fibrogenic, anti-apoptotic and pro-angiogenic. Besides, the use of adjuvant therapies, whose aim is to boost or synergize with their function should be tested. Low level laser (LLL) therapy is a relatively new and promising approach, with very low cost, no invasiveness and no side effects. Here, we aimed to study the effectiveness of human tube derived MSCs (htMSCs) cell therapy associated with a 30mW/3J-660 nm LLL irradiation in experimental cigarette smoke-induced chronic obstructive pulmonary disease. Thus, C57BL/6 mice were exposed to cigarette smoke for 75 days (twice a day) and all experiments were performed on day 76. Experimental groups receive htMSCS either intraperitoneally or intranasally and/or LLL irradiation either alone or in association. We show that co...Continue Reading

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Citations

Nov 18, 2017·PloS One·Larissa Carbonera CandeoAnna Carolina Ratto Tempestini Horliana
Nov 17, 2015·PloS One·Cristiane Miranda da SilvaAdriana Lino-Dos-Santos-Franco
Jul 18, 2017·Lasers in Medical Science·Robson Alexandre BrochettiAdriana Lino-Dos-Santos-Franco

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Methods Mentioned

BETA
hysterectomy
bronchoalveolar lavage
flow cytometry
lavage
ELISA

Software Mentioned

Prochymal
Image Pro Plus
GraphPad Prism
Image Pro - Plus
GraphPad

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