PMID: 2503456Aug 15, 1989Paper

Human tumor-infiltrating lymphocyte (TIL) cytotoxicity facilitated by anti-T-cell receptor antibody

International Journal of Cancer. Journal International Du Cancer
D D SchoofT J Eberlein

Abstract

Long-term growth of tumor-infiltrating lymphocytes (TIL) in high concentrations of rIL-2 is required for generation of therapeutic numbers of cells for adoptive immunotherapy of human cancer. Under these conditions rIL-2 promotes both anti-tumor cytotoxicity and lymphocyte growth from tumors of several histological types. In a series of 16 consecutive tumors, studies of TIL-mediated cytotoxicity against different tumor targets were characterized by an initial strong tumor-non-specific cytotoxicity. With time, TIL bulk cultures became non-cytotoxic against all targets (median time = 38 days). Non-cytotoxic TIL bulk populations were capable of mediating strong cytotoxic responses if pre-treated with anti-T-cell antigen receptor antibody (TcR) before addition to targets. TIL populations were not, however, uniformly susceptible to anti-TcR-mediated cytotoxicity. Anti-TcR-mediated cytotoxicity was confined to CD8+ bulk populations (defined as populations with a CD4/CD8 ratio less than 1), with virtually no cytotoxicity observed in CD4+ populations (CD4/CD8 ratio greater than 2, (p less than 0.01). Both CD4 and CD8 populations expressed TcR antigen reactive with anti-TcR antibody. These results indicate that, despite poor in vitro an...Continue Reading

References

Nov 1, 1988·The Journal of Experimental Medicine·F T RotteveelC J Lucas
Jan 1, 1986·Cancer Immunology, Immunotherapy : CII·T L WhitesideV von Fliedner
May 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S L TopalianP Simon
Aug 24, 1987·Journal of Immunological Methods·S L TopalianS A Rosenberg
Apr 9, 1987·The New England Journal of Medicine·W H WestR K Oldham

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Citations

Mar 17, 2001·International Journal of Cancer. Journal International Du Cancer·O ManzkeH Bohlen
Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·E W NijhuisR A van Lier
Apr 1, 1994·Cancer Treatment Reviews·J E GoldR J Krane

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