PMID: 591128Dec 15, 1977

Human tumour--lymphocyte interaction in vitro. V. Comparison of the reactivity of tumour-infiltrating, blood and lymph-node lymphocytes with autologous tumour cells

International Journal of Cancer. Journal International Du Cancer
B M VoseE Klein

Abstract

Lymphocytes prepared from the blood, tumour-draining lymph node and tumour were tested for immune reactivity with freshly isolated autologous tumour cells from biopsies. Reactivity was assessed by the autologous tumour stimulation assay and by lymphocytotoxicity. Activity was found in 6/11 blood preparations, 7/10 lymph nodes and 1/7 tumour-infiltrating lymphocytes in tumour stimulation assays and in 6/19 blood, 8/18 lymph-node and 5/20 tumour-infiltrating lymphocytes in cytotoxicity assays. Tests with material from patients with nasopharyngeal carcinoma showed a higher frequency of cytotoxicity in the tumour-infiltrating lymphocytes than in other solid tumours. There was a correlation between results of the two assays when performed on the same preparations and between the levels of reactivity in lymph node and blood from the same patient. Cytotoxicity in the lymph nodes showed specificity in that cells from a long-term culture (K562) known to be sensitive to natural killer activity and from allogeneic tumour biopsies were only rarely damaged. Cytotoxicity against K562 was more frequently determined in blood lymphocytes. Tumour-infiltrating lymphocytes were non-reactive in patients when the blood and lymph-node lymphocytes wer...Continue Reading

References

Jul 1, 1977·Journal of the National Cancer Institute·C B HansenS W Russell
Sep 1, 1976·Journal of the National Cancer Institute·H L Ioachim
Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·M Jondal, H Pross
Oct 15, 1977·International Journal of Cancer. Journal International Du Cancer·B M VoseE Klein
Jan 1, 1976·Annals of the New York Academy of Sciences·E KleinF Vánky
May 29, 1975·Nature·M JondalS Singh
Nov 15, 1975·International Journal of Cancer. Journal International Du Cancer·J S HaskillL Radov
Sep 1, 1973·British Journal of Cancer·C W Elston, K D Bagshawe
Aug 1, 1974·The Journal of Infectious Diseases·G Miller
Aug 15, 1974·International Journal of Cancer. Journal International Du Cancer·R VánkyU Nilsonne
Jan 1, 1970·Advances in Cancer Research·P Alexander, J G Hall
Nov 2, 1974·British Medical Journal·M Di PaolaS Colizza
Oct 1, 1973·European Journal of Immunology·M H JuliusL A Herzenberg

Citations

Jan 1, 1983·Cancer Metastasis Reviews·M Introna, A Mantovani
Jan 1, 1987·Journal of Cancer Research and Clinical Oncology·G BoltzA Gangl
Jan 1, 1988·Journal of Cancer Research and Clinical Oncology·W DrögeW Ebert
Jan 1, 1989·Cancer Immunology, Immunotherapy : CII·T Mainou-Fowler, O Eremin
Feb 1, 1985·Annals of Surgery·E C Holmes
May 21, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Y MaS Okada
Mar 1, 1980·International Journal of Radiation Oncology, Biology, Physics·R L Howell, C J Koch
Sep 15, 1980·Cellular Immunology·B M Vose
Jun 1, 1981·Cellular Immunology·G R FlanneryR W Baldwin
Oct 1, 1993·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·I YoshinoK Nomoto
Jun 1, 1982·Medical Hypotheses·D R McCluskey
Jan 1, 1985·The Journal of Surgical Research·P M MoyS H Golub
Jun 1, 1984·European Journal of Cancer & Clinical Oncology·G R FlanneryR W Baldwin
Feb 1, 1989·Journal of Surgical Oncology·S MiuraE Shiina
Oct 15, 1988·International Journal of Cancer. Journal International Du Cancer·M C KuppnerN de Tribolet
Jun 15, 1985·International Journal of Cancer. Journal International Du Cancer·J Hurlimann, P Saraga
Jan 15, 1980·International Journal of Cancer. Journal International Du Cancer·V SanterP K Lala
Jan 1, 1988·Annals of the New York Academy of Sciences·J H FinkeJ Montie
Mar 1, 1984·The Annals of Otology, Rhinology, and Laryngology·G CortesinaS Rendine
Jul 15, 2017·The British Journal of Radiology·William H McBrideDörthe Schaue
Jul 15, 1983·International Journal of Cancer. Journal International Du Cancer·A Uchida, M Micksche
Jul 1, 1996·Annals of the Rheumatic Diseases·A Zonana-NacachW W Daniel
Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·B M Vose, M Moore
Nov 1, 1980·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·J L Svennevig
Oct 1, 1994·Cancer Immunology, Immunotherapy : CII·R A JanssenL de Leij
Mar 1, 1981·Acta Pathologica Et Microbiologica Scandinavica. Section A, Pathology·J L Svennevig, J Holter
May 15, 1979·International Journal of Cancer. Journal International Du Cancer·J L SvennevigH Svaar
Oct 1, 1988·The Journal of Urology·H TsujihashiT Kurita
Aug 1, 1980·Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology·J Hammerstrøm
May 15, 1980·International Journal of Cancer. Journal International Du Cancer·A MantovaniC Mangioni
Jun 1, 1989·The Journal of Urology·H TsujihashiT Kurita

Related Concepts

Immunologic Tumoricidal Activities
Malignant Neoplasm of Lung
Lymph Nodes
Lymphocyte Activation
Lymphoid Cells
Cancer of Nasopharynx

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.