PMID: 6539698May 1, 1984Paper

Human tumour pH changes following hyperthermia and radiation therapy

European Journal of Cancer & Clinical Oncology
J L Wike-HooleyH S Reinhold

Abstract

Measurement of human tumour pH was performed during treatment with whole-body hyperthermia (WBHT) at 41.8 degrees C, and prior to and following a series of combined local hyperthermia (LHT) and radiotherapy treatments. During WBHT no changes were seen in the 11 tumour measurements performed during heating, 'plateau' and cooling phases of treatment. Tumour pH rose significantly in 24 tumours in which paired determinations were performed prior to and following local therapy (mean rise, 0.23 pH units), while the 11 subcutaneous controls, measured in a non-treated area, remained unchanged. The lack of change in tumour pH during WBHT is probably related to the moderate treatment temperature (42 degrees C or less), whereas the rise seen following local therapy is probably the result of changes in tissue oxygenation and blood flow following therapy. These changes may have implications to the treatment of malignant disease.

References

Aug 1, 1970·Archives of Surgery·P W WolpertF A Miller
May 1, 1982·European Journal of Cancer & Clinical Oncology·A P van den BergH S Reinhold
Sep 1, 1982·Clinical Radiology·R H Thomlinson
Nov 1, 1980·Radiology·H I BicherT O'Brien

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Citations

Apr 1, 1995·Journal of Photochemistry and Photobiology. B, Biology·S MordonS Soulié
Dec 18, 2008·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Ahmed Bettaieb, Diana A Averill-Bates
Jun 30, 2012·International Journal of Nanomedicine·Jae-Yoon ShinDae-Hyuk Kweon
Sep 1, 1985·International Journal of Radiation Oncology, Biology, Physics·A J ThistlethwaiteR E Nerlinger
Apr 19, 2015·Nanomedicine : Nanotechnology, Biology, and Medicine·Jesus Pacheco-TorresArmagan Kocer
Apr 1, 1986·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·H S Reinhold, B Endrich
May 14, 2016·Journal of Microencapsulation·Wei ZongXiaojun Han
Jan 20, 2017·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·A L OeiJ Crezee
Jan 5, 2020·Pharmaceutical Research·Joachim SchusterRoman Mathaes
Jul 1, 1991·International Journal of Radiation Biology·C W SongS K Sahu
Nov 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Gabriela CosíoCarmen Clapp
Mar 15, 2003·The Journal of Biological Chemistry·Adrienne L Goerges, Matthew A Nugent
Oct 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michaël Lora-MichielsMark W Dewhirst
Mar 17, 2021·Journal of Pharmaceutical Sciences·Joachim SchusterRoman Mathaes
Dec 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J L Wike-HooleyH S Reinhold

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