PMID: 3750245May 1, 1986Paper

Human tumour xenografts growing in immunodeficient mice: a useful model for assessing chemotherapeutic agents in bronchial carcinoma

Thorax
R J FergussonJ F Smyth

Abstract

Xenografts from eight human bronchial carcinomas have been established in CBA/Lac mice rendered immunodeficient by neonatal thymectomy followed three weeks later by whole body irradiation (7.35 Gy (735 rads)) after a priming dose of cytosine arabinoside. Growth rates of individual tumour lines remain constant and the histological and chromosomal characteristics of the original tumour are maintained through multiple serial passages over many months. With specific growth delay as the principal end point this system may be used to assess the response of histologically different lung tumours to chemotherapeutic agents.

References

Jun 1, 1976·Journal of the National Cancer Institute·Y ShimosatoT Nomura
Feb 1, 1978·British Journal of Cancer·G G SteelA Y Rostom
Jul 29, 1977·Science·A W Hamburger, S E Salmon
Apr 1, 1978·British Journal of Cancer·K NowakG G Steel
Feb 1, 1985·British Journal of Cancer·J MatternM Volm
Feb 9, 1985·British Medical Journal·S G Spiro
Oct 1, 1980·The British Journal of Surgery·A J ShorthouseM J Peckham
Oct 1, 1980·British Journal of Cancer·M J BaileyM J Peckham
Feb 1, 1984·The British Journal of Radiology·A M LeverJ J Gilmartin
Jan 1, 1983·British Journal of Cancer·G G SteelM J Peckham
Jun 1, 1981·Journal of the National Cancer Institute·A W Hamburger
May 1, 1980·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L KopperJ Timár
Jan 6, 1962·Lancet·E J AMBROSEJ A WYLIE

❮ Previous
Next ❯

Citations

Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·P F SheehanD H Barkla
Nov 1, 1987·Thorax·R J Fergusson, J F Smyth
Aug 16, 2014·Zeitschrift für medizinische Physik·Falk TillnerWolfgang Enghardt
Jan 3, 1995·International Journal of Cancer. Journal International Du Cancer·A OroszO Nyéki

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Bronchogenic

Bronchogenic Carcinoma is a malignant lung cancer arising in the epithelium of the bronchus or bronchiole. Discover the latest research on Bronchogenic Carcinoma here.

© 2021 Meta ULC. All rights reserved