PMID: 7544230Jan 1, 1995Paper

Human type I interferon receptor, IFNAR, is a heavily glycosylated 120-130 kD membrane protein

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
L E LingC D Benjamin

Abstract

Type I interferons (IFNs) bind and signal through cell surface receptors that share at least one common component. One candidate for such a component is the interferon-alpha receptor (IFNAR). Genetic studies have shown that the IFNAR gene product is required for response to many type I interferons. However, these studies also suggest that the IFNAR protein interacts with an additional receptor component(s) to form functionally complete type I IFN receptors. Although these genetic studies have contributed significantly to understanding the type I IFN receptors. Although these genetic studies have contributed significantly to understanding the type I IFN receptors, little biochemical characterization of IFNAR and its function has been reported. To facilitate biochemical studies of the IFNAR gene product, a monoclonal antibody, GB8, recognizing the extracellular domain of IFNAR was prepared. The epitope for GB8 maps to the second extracellular domain of IFNAR between amino acids 278 and 293. GB8 identifies IFNAR in western blots of cell membranes as a broad band with molecular mass ranging from 100 to 150 kD in membranes from CHO cells overexpressing the human IFNAR gene to 136-150 kD in Daudi cell membranes. Such variations in th...Continue Reading

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Citations

Aug 1, 1996·Cytokine & Growth Factor Reviews·P Domanski, O R Colamonici
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·M C GauzziS Pellegrini
Feb 27, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·L A GoldmanJ A Langer
Aug 13, 2011·Viral Immunology·Jared D EvansChristoph Seeger
Aug 24, 2002·Biology of Reproduction·Cheryl S RosenfeldR Michael Roberts
Sep 24, 1999·Protein Science : a Publication of the Protein Society·R M ArduiniD P Baker
Mar 13, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan McCormackNoula Shembade
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Oct 28, 2019·Nature Microbiology·Tingting GuoHui Zheng
Mar 23, 2006·The Biochemical Journal·Zrinka MarijanovicSandra Pellegrini
Feb 9, 2021·Frontiers in Immunology·Natacha ZaninCedric M Blouin

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