Human umbilical cord blood stem cells and brain-derived neurotrophic factor for optic nerve injury: a biomechanical evaluation

Neural Regeneration Research
Zhong-Jun ZhangMin Luo

Abstract

Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 10(6) human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury.

References

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Citations

Nov 28, 2015·Archivum Immunologiae Et Therapiae Experimentalis·Nan Xiao, Quynh-Thu Le
Dec 10, 2015·Stem Cells International·Louise A Mesentier-LouroMarcelo F Santiago
Nov 15, 2019·Muscle & Nerve·Carrie A KubiakStephen W P Kemp
Apr 3, 2020·The International Journal of Neuroscience·Peng LiDaliang Kong
Feb 29, 2020·Ophthalmology and Therapy·Giuseppe GiannaccareVincenzo Scorcia
Jun 18, 2021·World Journal of Stem Cells·Giovanni MiottiMarco Zeppieri

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Methods Mentioned

BETA
dissection
MDA
Scanning electron microscopy

Software Mentioned

SPSS

Related Concepts

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