Human uremic plasma increases microvascular permeability to water and proteins in vivo

Kidney International
Steven J HarperDavid O Bates

Abstract

The risk of cardiovascular disease is significantly higher in patients with long-term uremia than in otherwise healthy adults. This is true even before patients proceed to dialysis, but the reason why cardiovascular risk is increased is unknown. Transvascular transport of lipids and other macromolecules in both large vessels and the microcirculation has been implicated in generation of cardiovascular disease. To determine whether patients with long-term uremia have circulating factors that promote increased vascular permeability, we measured the effect of perfusing microvessels with uremic plasma in a non-mammalian model of vascular permeability measurement. Perfusion of frog mesenteric microvessels with dialyzed normal plasma did not result in an increase in either hydraulic conductivity (Lp, permeability of the vessel wall to water) or oncotic reflection coefficient (sigma, permeability to macromolecules, particularly proteins). Perfusion with dialyzed uremic plasma resulted in a very significant increase in vascular permeability to both water (Lp increased 8.8-fold from 4.1 to 36.4 x 10(-7) cm x s(-1) cm H2O(-1)) and proteins (sigma reduced from 0.93 to 0.53). These results suggest that one or more circulating macromolecules...Continue Reading

References

Jan 1, 1976·Scandinavian Journal of Immunology·S A Birkeland
Oct 1, 1974·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C C MichelP J Hunter
Dec 1, 1994·Kidney International·F K Port
Apr 1, 1994·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·F R Curry
Mar 1, 1997·Stroke; a Journal of Cerebral Circulation·S G WannametheeI J Perry
Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R JoannidesC Thuillez
Jul 29, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C van GuldenerC D Stehouwer
Nov 11, 1998·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·A SagripantiG Barsotti
Nov 20, 1998·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R N FoleyM J Sarnak
Aug 5, 1999·Kidney International·T MoeslingerP G Spieckermann
Aug 31, 1999·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·D O BatesB Williams
Jul 8, 2000·Kidney International·A K CheungA S Levey
Aug 11, 2000·Kidney International. Supplement·F MeeusG M London
Aug 30, 2000·Lancet·C BaigentD Wheeler

❮ Previous
Next ❯

Citations

Aug 31, 2011·Annals of Biomedical Engineering·Vaibhav MaheshwariGade P Rangaiah
Apr 16, 2003·Kidney International. Supplement·Steven J Harper, David O Bates
Apr 21, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zanzhe YuSimon J Davies
Dec 8, 2006·Seminars in Dialysis·Stefan John, Kai-Uwe Eckardt
Jun 21, 2011·Seminars in Dialysis·Noémie Jourde-ChichePhilippe Brunet
Feb 11, 2005·Nephron. Experimental Nephrology·Laurent DanielDominique Figarella-Branger
Feb 9, 2006·Blood Purification·A BreborowiczD G Oreopoulos
Oct 14, 2004·Intensive Care Medicine·Wilfred Druml
Oct 8, 2015·Kidney International·Francesco MarinoCarmine Zoccali
Jan 13, 2006·Journal of Thrombosis and Haemostasis : JTH·V FaureF Dignat-George
Dec 19, 2008·Hemodialysis International·Jochen RaimannPeter Kotanko
Jun 15, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·V L BillsD O Bates
Sep 28, 2015·Critical Care Clinics·Kai Singbartl, Michael Joannidis
Oct 6, 2018·Hemodialysis International·Cibele Puato de AlmeidaAndré Luís Balbi
Sep 18, 2018·The Annals of Pharmacotherapy·Ling YinPatricia Louzon-Lynch
Sep 27, 2014·Current Opinion in Critical Care·Wilfred Druml
Jul 31, 2014·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Cibele Puato AlmeidaAndre Luis Balbi
Jul 21, 2020·Computer Methods in Biomechanics and Biomedical Engineering·L PossentiP Zunino
Jun 28, 2018·Clinical and Experimental Nephrology·Cibele Puato AlmeidaDaniela Ponce
May 3, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marc Vila CuencaPeter L Hordijk
Oct 16, 2007·Chest·Stefan John, Kai-Uwe Eckardt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.