Human ureter, a source of tissue plasminogen activator

Thrombosis Research
H LjungnérM Pandolfi

Abstract

In organ cultures of human ureters, plasminogen activators were released into the medium. Unlike most tissue cultures that release mainly urokinase (UK), the activators released by ureter cultures were predominantly of the tissue-type (t-PA), as shown by radioimmunoassay. Using affinity chromatography it was possible to distinguish two activities. One minor fraction was quenched by antibodies against UK, but not by antibodies against t-PA. The other activity was quenched by antibodies against t-PA, but not by those against UK, and required the presence of fibrin to activate plasminogen. Because of the large amount of t-PA, cells derived from human ureter might well prove to be a useful source of t-PA.

References

Sep 1, 1983·Journal of Clinical Pathology·H LjungnérB Astedt
Jun 1, 1982·Scandinavian Journal of Clinical and Laboratory Investigation·L HolmbergB Astedt
Jun 1, 1982·Proceedings of the Society for Experimental Biology and Medicine·L HolmbergB Astedt
Feb 1, 1981·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B AstedtJ Thorell
Jul 1, 1959·The Journal of Pathology and Bacteriology·A S TODD

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Citations

Jul 9, 2003·Journal of Vascular and Interventional Radiology : JVIR·Tun Tin HtaikTimothy W I Clark
Mar 1, 1986·Acta Physiologica Scandinavica·A Kjaeldgaard, M Kjaeldgaard
Jan 1, 1987·Archives of Oral Biology·M Kjaeldgaard, A Kjaeldgaard
Nov 12, 1985·Biochimica Et Biophysica Acta·O Saksela
Dec 15, 1986·Thrombosis Research·A KjaeldgaardB Astedt

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