Abstract
To evaluate the efficacy of Human Urinary Kallidinogenase (HUK) for secondary stroke prevention in the treatment of acute ischemic stroke (AIS) patients. In this retrospective study, from October 2016 to June 2017, 300 consecutive AIS patients were registered in our database. Among them, 145 patients received HUK treatment (HUK group), and 155 patients received basic treatment (control group). Basic treatment was administrated on all patients. 0.15 PNA unit of HUK injection plus 100 ml saline in intravenous infusion was performed in the HUK group, with once a day for 14 consecutive days. The rate of recurrent stroke and modified Rankin Scale (mRS) scores in two groups were analyzed 12 months after the treatment. No difference was found in the age, gender, comorbidities, smoking history, and NIHSS scores between two groups before treatment (p > 0.05). 12 months after treatment, 10 patients in the HUK group (10.3%) and 26 patients in the control group (16.8%) got stroke recurrence at 12 months (p = 0.009). The mRS score of HUK group was significantly lower than that in the control group (2.3 ± 1.2 vs. 3.5 ± 1.4, p = 0.011). Human Urinary Kallidinogenase is able to reduce the risk of stroke recurrence and promote good recovery for...Continue Reading
References
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Julie Chao, Lee Chao
Feb 4, 2006·Human Gene Therapy·Chun-Fang XiaJulie Chao
May 24, 2006·Neurology·M KuboM Iida
Mar 7, 2008·Stroke; a Journal of Cerebral Circulation·Robert J AdamsUNKNOWN American Stroke Association
Mar 21, 2008·Brain Research·Li LingJinsheng Zeng
Aug 30, 2008·The New England Journal of Medicine·Ralph L SaccoUNKNOWN PRoFESS Study Group
Jan 24, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Oliver A StonePaolo Madeddu
Sep 19, 2009·Chest·Gregory Y H LipHarry J G M Crijns
Feb 25, 2010·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhi-bin ChenYun Xu
Jul 29, 2010·Cerebrovascular Diseases·Joachim Röther, Harry Crijns
Jan 21, 2012·Cerebrovascular Diseases·Vinayak PrasadRod S Passman
Dec 15, 2012·Circulation·Alan S GoUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Feb 19, 2013·PloS One·Zhan WangYongjun Wang
Mar 27, 2013·Journal of Evidence-based Medicine·Canfei ZhangDeren Wang
Jul 30, 2014·Journal of the American Society of Hypertension : JASH·Carlos A Feldstein
Jul 26, 2016·Biomedical Reports·Jiang Ke, Mou Jing
Jul 15, 2017·Stroke; a Journal of Cerebral Circulation·Lisa BergströmThomas Mooe
Aug 23, 2017·Brain and Behavior·Danhong WuXueyuan Liu