Human uterine and placental arteries exhibit tissue-specific acute responses to 17β-estradiol and estrogen-receptor-specific agonists.

Molecular Human Reproduction
Jemma J CorcoranM J Taggart

Abstract

The discrete regulation of vascular tone in the human uterine and placental circulations is a key determinant of appropriate uteroplacental blood perfusion and pregnancy success. Humoral factors such as estrogen, which increases in the placenta and maternal circulation throughout human pregnancy, may regulate these vascular beds as studies of animal arteries have shown that 17β-estradiol, or agonists of estrogen receptors (ER), can exert acute vasodilatory actions. The aim of this study was to compare how acute exposure to ER-specific agonists, and 17β-estradiol, altered human placental and uterine arterial tone in vitro. Uterine and placental arteries were isolated from biopsies obtained from women with uncomplicated pregnancy delivering a singleton infant at term. Vessels were mounted on a wire myograph, exposed to the thromboxane receptor agonist U46619 (10(-6) M), and then incubated with incremental doses (5 min, 0.03-30 µM) of either 17β-estradiol or agonists specific for the ERs ERα (PPT), ERβ (DPN) or the G-protein-coupled estrogen receptor GPER-1 (G1). ERα and ERβ mRNA expression was assessed. 17β-estradiol, PPT and DPN each relaxed myometrial arteries (P < 0.05) in a manner that was partly endothelium-dependent. In con...Continue Reading

References

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Citations

May 21, 2016·Frontiers in Physiology·Manuel MaliqueoNicolás Crisosto
Oct 1, 2016·International Journal of Environmental Research and Public Health·Jae-Hwan LeeEui-Bae Jeung
Oct 13, 2016·The Journal of Endocrinology·D S Boeldt, I M Bird
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Aug 15, 2014·Biology of Reproduction·Paula DíazThomas Jansson
Sep 8, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Mallikarjuna R PabbidiSumit P Sontakke
Nov 2, 2019·Cells·Xiang-Qun Hu, Lubo Zhang
Jun 24, 2020·International Journal of Molecular Sciences·Jin BaiDong-Bao Chen
Jul 11, 2020·Toxicological Sciences : an Official Journal of the Society of Toxicology·João MaiaGeorgina Correia-da-Silva
May 8, 2016·Clinical Science·Margaret A ZimmermanSarah H Lindsey
Sep 25, 2017·Scientific Reports·Christopher J NicholsonMichael J Taggart
May 12, 2018·International Journal of Molecular Sciences·Adela BanciuBeatrice Mihaela Radu
May 10, 2019·Frontiers in Pediatrics·Gaia Maria AnelliIrene Cetin
Aug 10, 2016·Journal of Cellular and Molecular Medicine·Christopher J NicholsonKathleen G Morgan
Sep 27, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Karina M MataRaouf A Khalil
Apr 7, 2018·Frontiers in Physiology·Sarah A MarshallMarianne Tare
Aug 28, 2021·International Journal of Molecular Sciences·Xiangqun Hu, Lubo Zhang

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Methods Mentioned

BETA
biopsies

Software Mentioned

Myodaq
Intelligent Quantifier

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