Human, vector and parasite Hsp90 proteins: A comparative bioinformatics analysis

FEBS Open Bio
Ngonidzashe FayaÖzlem Tastan Bishop

Abstract

The treatment of protozoan parasitic diseases is challenging, and thus identification and analysis of new drug targets is important. Parasites survive within host organisms, and some need intermediate hosts to complete their life cycle. Changing host environment puts stress on parasites, and often adaptation is accompanied by the expression of large amounts of heat shock proteins (Hsps). Among Hsps, Hsp90 proteins play an important role in stress environments. Yet, there has been little computational research on Hsp90 proteins to analyze them comparatively as potential parasitic drug targets. Here, an attempt was made to gain detailed insights into the differences between host, vector and parasitic Hsp90 proteins by large-scale bioinformatics analysis. A total of 104 Hsp90 sequences were divided into three groups based on their cellular localizations; namely cytosolic, mitochondrial and endoplasmic reticulum (ER). Further, the parasitic proteins were divided according to the type of parasite (protozoa, helminth and ectoparasite). Primary sequence analysis, phylogenetic tree calculations, motif analysis and physicochemical properties of Hsp90 proteins suggested that despite the overall structural conservation of these proteins, ...Continue Reading

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Citations

Feb 6, 2020·International Journal of Molecular Sciences·Olivier Sheik AmamuddyOzlem Tastan Bishop
Jun 20, 2017·Parasite : Journal De La Société Française De Parasitologie·Hongchao SunAifang Du
Feb 8, 2019·Malaria Journal·Dorothy Wavinya Nyamai, Özlem Tastan Bishop
Aug 7, 2021·Pathogens·Boontarikaan WititkornkulRussell M Morphew
Jan 30, 2018·Journal of Chemical Information and Modeling·David L PenklerÖzlem Tastan Bishop

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Software Mentioned

MODELLER
Python
INS
MEGA6
Jalview
Netphos
Matlab script
PyMOL
MAST
Biopython

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