Human VIP-alpha: a long-acting, biocompatible and biodegradable peptide nanomedicine for essential hypertension

Peptides
Hayat OnyükselIsrael Rubinstein

Abstract

We have previously shown that self-association of human vasoactive intestinal peptide with sterically stabilized liposomes (VIP-alpha) alters peptide conformation from random coil in aqueous solution to alpha-helix. This, in turn, protects the peptide from hydrolysis and amplifies and prolongs its bioactivity. The purpose of this study was to determine whether a single, intravenous injection of low-dose human VIP-alpha normalizes systemic arterial pressure in anesthetized spontaneously hypertensive hamsters for a prolonged period of time in a selective fashion. We found that intravenous injection of human VIP-alpha, VIP alone (each, 1.0 nmol) and empty liposomes had no significant effects on mean arterial pressure (MAP) in normotensive hamsters. By contrast, human VIP-alpha (0.01-1.0 nmol) evoked a significant concentration-dependent decrease in MAP to the normative range in spontaneously hypertensive hamsters that lasted throughout the observation period (6 h; p<0.05). VIP alone and empty liposomes had no significant effects on MAP in these animals. We conclude that a single, low-dose intravenous injection of human VIP-alpha normalizes systemic arterial pressure in spontaneously hypertensive hamsters for a prolonged period of ...Continue Reading

References

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Citations

Mar 9, 2012·Pharmaceutical Research·Amrita Banerjee, Hayat Onyuksel
Dec 6, 2012·Molecular Pharmaceutics·Varun SethiHayat Onyuksel
Feb 24, 2016·International Journal of Pharmaceutics·Nada MatouguiPatrick Saulnier
Nov 26, 2015·Therapeutic Delivery·Jinjin ZhangTatiana K Bronich
Aug 1, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Amrita Banerjee, Hayat Onyuksel
Mar 7, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A BeloquiA Rodríguez-Gascón
Jul 8, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karin WernigAndreas Zimmer
Oct 26, 2007·Biomacromolecules·Julie ThevenotCatherine Ladavière
Jun 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sok Bee LimHayat Önyüksel

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