Human visceral leishmaniasis expresses Th1 pattern in situ liver lesions

The Journal of Infection
Maria Irma Seixas DuarteRoosecelis Araujo Brasil

Abstract

The architectural and infiltrate pattern of liver human visceral leishmaniasis (HVL) have been systematically classified as typical, fibrogenic or nodular. Despite this histopathological classification, the immune response based on cytokines and cellular phenotypes have never been performed. The aim of this study was to determine the immunophenotypic pattern and cytokine profile of the nodular involvement of the liver in HVL. We evaluated nine cases of the nodular form of HVL. In situ immune response was studied through cytokine analysis and immunohistochemical study for phenotype markers: IL-1, IL-4, IL-10, TNF-alpha, IFN-gamma, CD4+ T cells, CD8+ T cells, CD20, CD68, CD57 and macrophage activation was determined by evaluation of iNOS activity. HVL seems to be related to a better immune response. Amastigotes were rarely found on liver sections. Leishmania antigen expression was also rare and located in the inflammatory nodules. The lower expression of IL-4 and IL-10, moderate expression of TNF-alpha and IFN-gamma demonstrate a panorama of Th1 phenotype. The increased expression of NK cells could help in sustaining this model of response. This pattern of immune response is probably responsible for improvement in the parasite's ...Continue Reading

References

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Citations

Dec 25, 2013·Veterinary Immunology and Immunopathology·Alexandre Barbosa ReisOlindo de Assis Martins-Filho
Aug 16, 2016·Veterinary Parasitology·Pamela Rodrigues Reina MoreiraRosemeri de Oliveira Vasconcelos
Apr 6, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Pradyot Bhattacharya, Nahid Ali
May 29, 2012·Revista Do Instituto De Medicina Tropical De São Paulo·Felipe Francisco TuonValdir Sabbaga Amato
Nov 7, 2009·Revista Do Instituto De Medicina Tropical De São Paulo·Hiro Goto, Maria das Graças Prianti

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