Human visceral nociception: findings from translational studies in human tissue

American Journal of Physiology. Gastrointestinal and Liver Physiology
James R F HockleyDavid C Bulmer

Abstract

Peripheral sensitization of nociceptors during disease has long been recognized as a leading cause of inflammatory pain. However, a growing body of data generated over the last decade has led to the increased understanding that peripheral sensitization is also an important mechanism driving abdominal pain in highly prevalent functional bowel disorders, in particular, irritable bowel syndrome (IBS). As such, the development of drugs that target pain-sensing nerves innervating the bowel has the potential to be a successful analgesic strategy for the treatment of abdominal pain in both organic and functional gastrointestinal diseases. Despite the success of recent peripherally restricted approaches for the treatment of IBS, not all drugs that have shown efficacy in animal models of visceral pain have reduced pain end points in clinical trials of IBS patients, suggesting innate differences in the mechanisms of pain processing between rodents and humans and, in particular, how we model disease states. To address this gap in our understanding of peripheral nociception from the viscera and the body in general, several groups have developed experimental systems to study nociception in isolated human tissue and neurons, the findings of ...Continue Reading

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Citations

Dec 20, 2018·Frontiers in Cellular Neuroscience·Stuart M BrierleyNick J Spencer
Jul 11, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Alan E LomaxDervla O'Malley
Jan 22, 2020·Physiological Reports·Toni S TaylorEwan St John Smith
Jan 22, 2022·ACS Chemical Neuroscience·Hongji Wang, Changshui Xu

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Methods Mentioned

BETA
dissection
surgical resection

Clinical Trials Mentioned

NCT00101985

Software Mentioned

Anabios
IT DRGNet
CRACK

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