DOI: 10.1101/495143Dec 13, 2018Paper

Human visual cortex is organized along two genetically opposed hierarchical gradients with unique developmental and evolutionary origins

BioRxiv : the Preprint Server for Biology
Jesse GomezKevin S Weiner


Human visual cortex is organized with striking consistency across individuals. While recent findings demonstrate an unexpected coupling between functional and cytoarchitectonic regions relative to the folding of human visual cortex, a unifying principle linking these anatomical and functional features of cortex remains elusive. To fill this gap in knowledge, we combined independent and ground truth measurements of human cytoarchitectonic regions and genetic tissue characterization within the visual processing hierarchy. Using a data-driven approach, we examined if differential gene expression among cortical areas could explain the organization of the visual processing hierarchy into early, middle, and late processing stages. This approach revealed that the visual processing hierarchy is explained by two opposing gene expression gradients: one that contains a series of genes with expression magnitudes that ascend from the first processing stage (e.g. area hOc1, or V1) to the last processing stage (e.g. area FG4) and another that contains a separate series of genes that show a descending gradient. In the living human brain, each of these gradients correlates strongly with anatomical variations along the visual hierarchy such as t...Continue Reading

Related Concepts

Body Regions
Cerebral Cortex
Gene Expression
Promoter Regions, Genetic
Visual Cortex
Protein Folding
HOC1 protein

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