PMID: 6108728Oct 1, 1980Paper

Human volunteer studies of Alfentanyl (R39209), a new short-acting narcotic analgesic

Anaesthesia
B Kay, B J Pleuvry

Abstract

Alfentanyl is a new narcotic analgesic with a rapid onset and very short duration of effect, and a potency about one third of that of fentanyl. The respiratory effects of 1.6, 3.2 and 6.4 micrograms/kg Alfentanyl were studied in a randomised controlled trial in five volunteers. Alfentanyl 6.4 micrograms/kg induced a significant increase in respiration at 1 minute, then significant depression of mean minute volume 3 and 4 minutes after slow intravenous injection, compared with saline control, and pre-injection values. Mean end-expired carbon dioxide concentration was increased after Alfentanyl 6.4 micrograms/kg, significantly from 2 to 9 min after injection, and highly significantly at 3, 4 and 5 minutes. Examination of the effect on expired CO2 concentration at 4 minutes reveals a highly significant dose-response relationship with the three doses of Alfentanyl. The transient effect of ALfentanyl was confirmed by the fact that no change in mean ventilatory response to carbon dioxide was demonstrable 30 or 50 minutes after any dose. When Alfentanyl was given 1 minute before testing the ventilatory response to carbon dioxide the response curves showed a highly significant dose-related shift to the right. There were no significant ...Continue Reading

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Citations

Jan 1, 1988·Intensive Care Medicine·M E SinclairA Fisher
May 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J J MulroyD R Cook
Jan 1, 1983·Canadian Anaesthetists' Society Journal·J NautaJ van Kleef
Sep 1, 1985·Canadian Anaesthetists' Society Journal·D P Cartwright
Sep 1, 1988·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·A B Enright, J B Parker
Jan 1, 1990·Acta Anaesthesiologica Scandinavica·M SfezJ M Rosemblatt
Mar 16, 2013·Saudi Journal of Anaesthesia·Christine Dagher
Apr 1, 1984·Journal of Pharmacological Methods·R L WynnF G Rudo
Jan 8, 2008·Journal of Molecular Graphics & Modelling·Sofie Van DammePatrick Bultinck
Jun 1, 1991·Journal of Dentistry·R Burtles
Jun 1, 1984·Anaesthesia·T E BlackT E Healy

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