Human Wharton's jelly mesenchymal stem cell secretome display antiproliferative effect on leukemia cell line and produce additive cytotoxic effect in combination with doxorubicin

Tissue & Cell
Fatemeh HendijaniHojjat Sadeghi-Aliabadi

Abstract

Mesenchymal stem cell (MSC) therapy moves toward clinic progressively. Recent evidences establish anticancer effect of mesenchymal stem cells. However multiple factors including type of cancer, MSC source, study design, and animal model play role in final outcome. Wharton's jelly - a newly approved source of MSCs - possesses superiorities to bone marrow as the conventional source; therefore investigation of its medical effects can produce beneficial results. In this survey we examined cytotoxic and proapoptotic effect of human Wharton's jelly MSC secretome on K562 human leukemia cells. MSCs were isolated from human Wharton's jelly of umbilical cord by explant culture method, then characterized according to ISCT criteria (morphology and plastic adherence, surface antigenicity and differentiation potential). MSC secretome was collected and its cytotoxic and proapoptotic effects on K562 cells in combination with doxorubicin were evaluated using BrdU cell proliferation assay and Annexin V-PI staining. Our results showed antiproliferative effect of mesenchymal stem cell secretome on K562 cancer cells, the effect was also added to cytotoxic effect of doxorubicin without induction of drug resistance. Human Wharton's jelly derived mese...Continue Reading

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Citations

Feb 23, 2019·Microscopy Research and Technique·Xiufeng Li, Zongming Li
Aug 6, 2019·Stem Cells·Sanam L Kavari, Khalid Shah
Dec 21, 2019·Advanced Pharmaceutical Bulletin·Mansoureh MirabdollahiHojjat Sadeghi-Aliabadi
Feb 23, 2020·Tissue Engineering. Part B, Reviews·Ingrid GarzonMiguel A Martin-Piedra
Jul 25, 2019·Cell and Tissue Banking·Mansoureh MirabdollahiHojjat Sadeghi-Aliabadi
Jul 9, 2020·Frontiers in Cell and Developmental Biology·Andrea PapaitAntonietta Rosa Silini
Dec 12, 2018·Stem Cell Research & Therapy·Ioannis ChristodoulouVassilis Zoumpourlis
Jul 23, 2020·Stem Cells International·Yang JiaoBingrong Zheng
Nov 27, 2020·Frontiers in Bioengineering and Biotechnology·Taja Železnik RamutaMateja Erdani Kreft
Aug 8, 2021·International Journal of Molecular Sciences·Katie DunphyDespina Bazou

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