Human whole-blood (1)H2O longitudinal relaxation with normal and high-relaxivity contrast reagents: influence of trans-cell-membrane water exchange

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Gregory J WilsonJeffrey H Maki

Abstract

Accurate characterization of contrast reagent (CR) longitudinal relaxivity in whole blood is required to predict arterial signal intensity in contrast-enhanced MR angiography (CE-MRA). This study measured the longitudinal relaxation rate constants (R1 ) over a concentration range for non-protein-binding and protein-binding CRs in ex vivo whole blood and plasma at 1.5 and 3.0 Tesla (T) under physiologic arterial conditions. Relaxivities of gadoteridol, gadobutrol, gadobenate, and gadofosveset were measured for [CR] from 0 to 18 mM [mmol(CR)/L(blood)]: the latter being the upper limit of what may be expected in CE-MRA. In plasma, the (1) H2 O R1 [CR]-dependence was nonlinear for gadobenate and gadofosveset secondary to CR interactions with the serum macromolecule albumin, and was well described by an analytical expression for effective 1:1 binding stoichiometry. In whole blood, the (1) H2 O R1 [CR]-dependence was markedly non-linear for all CRs, and was well-predicted by an expression for equilibrium exchange of water molecules between plasma and intracellular spaces using a priori parameter values only. In whole blood, (1) H2 O R1 exhibits a nonlinear relationship with [CR] over 0 to 18 mM CR. The nonlinearity is well described ...Continue Reading

References

May 1, 1989·The American Journal of Physiology·M D Herbst, J H Goldstein
Jan 1, 1974·Acta Anatomica·Y Yokoh
Jul 1, 1994·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M DonahueM L Gray
Jan 1, 1997·Journal of Magnetic Resonance Imaging : JMRI·K M DonahueD Burstein
Jan 13, 2000·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·S AimeE Terreno
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·C S LandisC S Springer
Mar 21, 2002·Journal of the American Chemical Society·Peter CaravanRandall B Lauffer
Aug 23, 2005·Bio Systems·Philip W Kuchel, Gheorghe Benga
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Dec 29, 2006·Contrast Media & Molecular Imaging·Sophie LaurentRobert N Muller
Dec 7, 2007·Contrast Media & Molecular Imaging·Virginie HenrotteLuce Vander Elst
Feb 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yan WangPeter Caravan
Jan 21, 2012·Biophysical Journal·Yajie ZhangJames A Balschi
May 15, 2012·Journal of Magnetic Resonance·Xin LiCharles S Springer

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Citations

May 20, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Scott B ReederDiego Hernando
Sep 27, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinjin ZhangMichael Garwood
May 7, 2014·NMR in Biomedicine·Charles S SpringerWei Huang
Dec 8, 2017·Investigative Radiology·Gesine KnoblochScott B Reeder
May 17, 2019·Journal of Magnetic Resonance Imaging : JMRI·Jeffrey H MakiToshimasa J Clark
Apr 29, 2015·NMR in Biomedicine·William D RooneyCharles S Springer
Jun 15, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gregory J WilsonJeffrey H Maki
Aug 2, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Toshimasa J ClarkJeffrey H Maki
May 6, 2016·Journal of Magnetic Resonance Imaging : JMRI·Gregory J Wilson, Jeffrey H Maki
Jun 20, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Valerie C AndersonWilliam D Rooney
Mar 25, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Xin LiCharles S Springer
Nov 7, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ruiliang BaiPeter J Basser
Jan 9, 2016·Biochimica Et Biophysica Acta·Eliana GianolioSilvio Aime

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