Humanistic and economic impact of subcutaneous versus intravenous administration of oncology biologics

Future Oncology
Kenneth C AndersonIra A Jacobs

Abstract

More oncology biologics are becoming available for subcutaneous (sc.) administration and are expected to provide useful therapeutic options. We evaluated evidence published in the past 5 years to assess the humanistic and economic impact of sc. versus intravenous administration of approved cancer therapies and identify outcomes favoring either administration route. These publications focused predominantly on healthcare resource utilization and economic outcomes, demonstrating resource and cost savings with sc. administration. Patients reported a better health-related quality of life and preference for sc. formulations. Time-and-motion study analyses confirmed the convenience of sc. administration. These findings suggest that future availability of sc. oncology biologics, especially anti-programmed death 1 (PD-1)/PD-ligand 1 (PD-L1) antibodies due to their increased utility in various malignancies, may be beneficial for patients, healthcare providers and payers.

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Citations

Aug 5, 2020·Expert Opinion on Biological Therapy·Barry PaulSaad Z Usmani
Jul 14, 2020·Expert Review of Hematology·Barry PaulSaad Z Usmani
Jun 13, 2021·Expert Opinion on Biological Therapy·Virginia SolitanoSilvio Danese
Jul 30, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fudan ZhengTonglei Li

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