PMID: 9664585Jul 17, 1998Paper

Humanized anti-L-selectin monoclonal antibody DREG200 therapy in acute thromboembolic stroke

Neurological Research
M M BednarV Vexler

Abstract

Strategies directed against activated neutrophils have reduced ischemia-induced brain injury. However, therapies targeted specially against the neutrophil adhesion protein L-selectin have not yet been examined in stroke. This study therefore examined the effects of a monoclonal antibody directed against L-selectin in a rabbit model of thromboembolic stroke with (n = 16) or without (n = 10) concomitant t-PA therapy. Rabbits received either the humanized monoclonal antibody DREG200 directed against the L-selectin receptor or humanized control monoclonal antibody HuDREG55 which does not bind to rabbit L-selectin in addition to t-PA therapy (n = 8, each group). HuDREG200 (2 mg kg-1 i.v.) was given as a bolus 3 h following clot embolization, followed immediately by a 2 h intravenous infusion of t-PA (6.3 mg kg-1. Without t-PA therapy rabbits received HuDREG200 (2 mgkg-1, i.v.; n = 5) or HuDREG55 (n = 5) 1 h following clot embolization. The group receiving HuDREG200 in addition to t-PA demonstrated a moderate improvement in brain infarct size (8.4 +/- 2.4 vs. 13.5 +/- 3.5, %hemisphere, mean +/- sem), ICP (final reading 10.0 +/- 1.6 vs. 12.4 +/- 3.0 torr) and restoration in regional cerebral blood flow (30.2 +/- 7.8 vs. 21.6 +/- 10.9 ...Continue Reading

Citations

Aug 8, 2018·Therapeutic Advances in Neurological Disorders·Antoine DrieuMarina Rubio
Oct 8, 2013·Translational Stroke Research·Chye Yun YuPing Liao
Mar 26, 2015·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Glen C JicklingFrank R Sharp
Aug 3, 2002·Stroke; a Journal of Cerebral Circulation·C J M Frijns, L J Kappelle
Dec 7, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hedley C A Emsley, Pippa J Tyrrell
Jan 4, 2001·Stroke; a Journal of Cerebral Circulation·K BeckerR Winn
Feb 11, 2000·Brain Pathology·P Kubes, P A Ward
Apr 27, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Xiaoye MoZhiping Hu
Oct 9, 2002·Current Medical Research and Opinion·Kyra J Becker
Oct 2, 2008·Neurological Research·Gokhan Yilmaz, D Neil Granger
Jan 25, 2017·Journal of Neuroinflammation·Vibha ShuklaKunjan R Dave
Dec 1, 2006·Clinical Neuroscience Research·Zinaida S VexlerMidori A Yenari

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