Humanized Mouse Models of Staphylococcus aureus Infection

Frontiers in Immunology
Dane Parker

Abstract

Staphylococcus aureus is a successful human pathogen that has adapted itself in response to selection pressure by the human immune system. A commensal of the human skin and nose, it is a leading cause of several conditions: skin and soft tissue infection, pneumonia, septicemia, peritonitis, bacteremia, and endocarditis. Mice have been used extensively in all these conditions to identify virulence factors and host components important for pathogenesis. Although significant effort has gone toward development of an anti-staphylococcal vaccine, antibodies have proven ineffective in preventing infection in humans after successful studies in mice. These results have raised questions as to the utility of mice to predict patient outcome and suggest that humanized mice might prove useful in modeling infection. The development of humanized mouse models of S. aureus infection will allow us to assess the contribution of several human-specific virulence factors, in addition to exploring components of the human immune system in protection against S. aureus infection. Their use is discussed in light of several recently reported studies.

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Citations

Sep 7, 2018·Scientific Reports·Emily E RadkeGregg J Silverman
May 1, 2020·Frontiers in Microbiology·Angelino T Tromp, Jos A G van Strijp
Jul 30, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jayaram Lakshmaiah NarayanaGuangshun Wang
Mar 2, 2021·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Ole Lerberg NielsenMaria Josefine Reimann
Mar 18, 2021·Scientific Reports·Rasmus Birkholm GrønnemoseThomas Emil Andersen
Oct 1, 2020·International Journal of Molecular Sciences·Daniel M MrochenSilva Holtfreter
Jul 4, 2019·Microbiology Spectrum·Timothy J Foster
May 15, 2020·The Journal of Investigative Dermatology·Christine YounLloyd S Miller

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Methods Mentioned

BETA
transgenic
transgenics

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