Humanized NOG mice as a model for tuberculosis vaccine-induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis

Immunology
Ajay GroverAngelo A Izzo

Abstract

The humanized mouse model has been developed as a model to identify and characterize human immune responses to human pathogens and has been used to better identify vaccine candidates. In the current studies, the humanized mouse was used to determine the ability of a vaccine to affect the immune response to infection with Mycobacterium tuberculosis. Both human CD4+ and CD8+ T cells responded to infection in humanized mice as a result of infection. In humanized mice vaccinated with either BCG or with CpG-C, a liposome-based formulation containing the M. tuberculosis antigen ESAT-6, both CD4 and CD8 T cells secreted cytokines that are known to be required for induction of protective immunity. In comparison to the C57BL/6 mouse model and Hartley guinea pig model of tuberculosis, data obtained from humanized mice complemented the data observed in the former models and provided further evidence that a vaccine can induce a human T-cell response. Humanized mice provide a crucial pre-clinical platform for evaluating human T-cell immune responses in vaccine development against M. tuberculosis.

References

Dec 1, 1993·The Journal of Experimental Medicine·J L FlynnB R Bloom
Dec 1, 1993·The Journal of Experimental Medicine·A M CooperI M Orme
Jun 24, 1993·Nature·G M AldrovandiJ A Zack
Jun 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D N McMurray
Apr 5, 2002·Clinical Microbiology Reviews·Reinout van CrevelJos W M van der Meer
Feb 3, 2005·Tuberculosis·Angelo IzzoIan Orme
Jul 14, 2005·Nature Reviews. Microbiology·Peter Andersen, T Mark Doherty
Oct 13, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ulrike Wille-ReeceRobert A Seder
Jun 24, 2006·The Journal of Clinical Investigation·Christopher H ParsonsDean H Kedes
May 18, 2007·Nature·Nathan D WolfeJared Diamond
Aug 22, 2008·Journal of Medical Primatology·Moshe BushmitzUNKNOWN EPV-Tuberculosis Working Group on Non-human Primate Health
Feb 19, 2009·European Journal of Immunology·Jayne S SutherlandMartin O C Ota
Mar 14, 2009·European Journal of Immunology·Paul J Maglione, John Chan
Jun 3, 2009·The Journal of Experimental Medicine·Till StrowigChristian Münz
Aug 7, 2009·Journal of Virology·Amanda Kwant-MitchellKenneth L Rosenthal
Oct 17, 2009·The Journal of Infectious Diseases·Misako YajimaShigeyoshi Fujiwara
May 25, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Santhi GorantlaLarisa Y Poluektova
Jun 12, 2010·European Journal of Immunology·Nadia CaccamoFrancesco Dieli
Aug 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stephen J LibbyFerric C Fang
Jan 5, 2011·Cellular & Molecular Immunology·M Firoz MianAli A Ashkar
Jan 26, 2011·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Mario RoedererMartha C Nason
Apr 13, 2011·PloS One·Ludovic ArnoldPierre Druilhe
Jul 18, 2012·Immunology and Cell Biology·Jennifer L TaylorAngelo A Izzo
Jan 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Julie LangRoberta Pelanda
Mar 19, 2013·Cell Host & Microbe·Jacqueline M Achkar, Arturo Casadevall
Apr 6, 2013·Proceedings of the National Academy of Sciences of the United States of America·Frank HeutsMartin E Rottenberg
May 22, 2013·PloS One·Veronica E CalderonJanice J Endsley
Aug 6, 2013·European Journal of Immunology·Carol LeungChristian Münz
Dec 4, 2013·Cold Spring Harbor Perspectives in Medicine·Andreas Bäumler, Ferric C Fang
Feb 24, 2015·Immunological Reviews·JoAnne L FlynnPhilana Ling Lin

❮ Previous
Next ❯

Citations

Feb 8, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Kylie Su Mei YongQingfeng Chen
Apr 17, 2018·Pathogens and Disease·César Pedroza-Roldán, Mario Alberto Flores-Valdez
Dec 1, 2018·Pathogens and Disease·Michel de Jesús Aceves-SánchezHelle Bielefeldt-Ohmann
Jun 7, 2018·Nature Reviews. Immunology·Hao Li, Babak Javid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.