Humans and Mice Display Opposing Patterns of "Browning" Gene Expression in Visceral and Subcutaneous White Adipose Tissue Depots

Frontiers in Cardiovascular Medicine
Maria A ZuriagaKenneth Walsh

Abstract

Visceral adiposity is much more strongly associated with cardiometabolic disease in humans than subcutaneous adiposity. Browning, the appearance of brown-like adipocytes in the white adipose tissue (WAT), has been shown to protect mice against metabolic dysfunction, suggesting the possibility of new therapeutic approaches to treat obesity and type 2 diabetes. In mice, subcutaneous WAT depots express higher levels of browning genes when compared with visceral WAT, further suggesting that differences in WAT browning could contribute to the differences in the pathogenicity of the two depots. However, the expression of browning genes in different WAT depots of human has not been characterized. Here, it is shown that the expression of browning genes is higher in visceral than in subcutaneous WAT in humans, a pattern that is opposite to what is observed in mice. These results suggest that caution should be applied in extrapolating the results of murine browning gene expression studies to human pathophysiology.

References

May 1, 1983·Bioscience Reports·D G Nicholls
Jun 1, 1997·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M Ghorbani, J Himms-Hagen
Mar 20, 1998·The Journal of Clinical Endocrinology and Metabolism·S K FriedA S Greenberg
May 3, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jan NedergaardBarbara Cannon
Feb 27, 2009·Diabetes Care·Stacy A PorterCaroline S Fox
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Jul 1, 2009·Diabetes·Patrick Seale, Mitchell A Lazar
Apr 9, 2010·Cell Metabolism·Sven Enerbäck
Apr 9, 2010·Cell Metabolism·Jan Nedergaard, Barbara Cannon
Jun 2, 2010·Nature Reviews. Drug Discovery·Yu-Hua TsengC Ronald Kahn
Dec 3, 2010·The Journal of Clinical Investigation·Patrick SealeBruce M Spiegelman
Dec 15, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J M Overton
Dec 24, 2010·The Journal of Experimental Biology·Barbara Cannon, Jan Nedergaard
Jan 25, 2011·Nature Medicine·Alexander BarteltJoerg Heeren
Apr 28, 2011·Clinical Endocrinology·Mark StephensD Aled Rees
Aug 26, 2011·The Journal of Clinical Endocrinology and Metabolism·Tracey McLaughlinFahim Abbasi
Nov 19, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Melissa G FarbNoyan Gokce
Sep 20, 2012·JAMA : the Journal of the American Medical Association·Ian J NeelandJames A de Lemos
Dec 19, 2012·Biochimica Et Biophysica Acta·M Luisa BonetAndreu Palou
Feb 8, 2013·Genes & Development·Jun WuBruce M Spiegelman
Apr 16, 2013·Cell Metabolism·Tamara TchkoniaJames L Kirkland
Oct 9, 2013·Nature Medicine·Matthew Harms, Patrick Seale
Apr 10, 2014·The Journal of Clinical Investigation·Ippei ShimizuKenneth Walsh
May 21, 2014·The Journal of Clinical Endocrinology and Metabolism·Victoria CatalánGema Frühbeck
Jul 22, 2014·Cell Metabolism·Michele PetruzzelliErwin F Wagner
Nov 5, 2014·Physiology·Shane K MaloneyJ Michael Overton
Jun 9, 2015·Diabetes·Kristin I StanfordLaurie J Goodyear
Nov 21, 2015·Cell Reports·David PatsourisMarc G Jeschke
Aug 5, 2016·The American Journal of Clinical Nutrition·Asif NakhudaJames A Timmons
Jan 23, 2017·Biochimie·Anastasia V KalinovichJan Nedergaard

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Citations

Dec 1, 2017·International Journal of Obesity : Journal of the International Association for the Study of Obesity·T TsiloulisM J Watt
Jul 13, 2019·The Journal of Physiology·Greg L McKieDavid C Wright
Sep 25, 2017·Hormone Molecular Biology and Clinical Investigation·Melania GagginiAmalia Gastaldelli
Jul 10, 2018·Pflügers Archiv : European journal of physiology·Logan K Townsend, David C Wright
Feb 15, 2019·Frontiers in Physiology·Shireesh Srivastava, Richard L Veech
Jun 27, 2019·American Journal of Physiology. Endocrinology and Metabolism·Malini S IyerMorvarid Kabir
Mar 3, 2020·Frontiers in Physiology·Claire LaurensCedric Moro
Feb 16, 2019·Frontiers in Physiology·Ferran ComasJosé María Moreno-Navarrete
Oct 18, 2019·Frontiers in Physiology·Bàrbara ReynésAndreu Palou
May 31, 2019·The Journal of Endocrinology·Carsten T Herz, Florian W Kiefer
Mar 12, 2020·Frontiers in Cardiovascular Medicine·Alan Chait, Laura J den Hartigh
Nov 30, 2019·Clinical Science·Sarah R AnthonyMichael Tranter
May 16, 2020·Frontiers in Endocrinology·Pablo Vidal, Kristin I Stanford
Apr 14, 2019·Biology·Quyen LuongKevin Y Lee
Jan 23, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Jisun LimYoonseok Heo
Jun 23, 2020·Journal of Molecular Cell Biology·Hai-Bin Ruan
Dec 1, 2020·American Journal of Physiology. Endocrinology and Metabolism·Martine AuclairBénédicte Antoine
Jan 29, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Celestina MazzottaNoyan Gokce
Jan 12, 2021·Frontiers in Endocrinology·Magdalena LeivaGuadalupe Sabio
Feb 13, 2021·Molecular Therapy. Methods & Clinical Development·Nicholas J QueenLei Cao
Oct 31, 2020·Frontiers in Endocrinology·Gabriella Simões HeynKelly Grace Magalhães
Dec 6, 2020·Cells·Lauriane Y M MichelJean-Luc Balligand
Feb 28, 2021·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Rebeca OrtegaLaura Piqueras
Jul 31, 2021·Journal of the American College of Cardiology·Matthew NayorRavi V Shah
Aug 17, 2021·Frontiers in Endocrinology·Anna GoddiRonald N Cohen
Aug 23, 2021·The Journal of Nutritional Biochemistry·Sabrina FolieSusanne Kaser
Oct 5, 2021·Archives of Pharmacal Research·Kwang-Hoon Chun
Dec 16, 2021·Evolutionary Anthropology·Stephanie B Levy, William R Leonard

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