Abstract
Humic acid was previously shown to enhance cutaneous wound healing and show antibacterial properties; however, it has not been used for wound healing in the oral cavity. Thus, the goal of this study was the evaluation of the effect of the humic acid on the healing of excisional wounds in an experimental rat study. A circular wound on mid-palatal surfaces was made on a total of 77 Wistar rats by using a 3-mm biopsy punch under anesthesia. The animals were divided into 4 groups as baseline, saline control (0.09%), chlorhexidine gluconate (0.05%), and humic acid (80 mg/kg) and were treated with these materials for 7 days. The rats were observed for 3 weeks in order to track the wound closure rates. Both humic acid treatment and chlorhexidine gluconate treatment resulted in statistically significant enhanced rate of wound closure compared to the saline control on both the 1st and 2nd weeks of treatment. Humic acid treatment for the wounds in the palate resulted in enhanced recovery compared to not only saline control but also chlorhexidine gluconate treatment. In this study, humic acid was shown to enhance healing of oral wounds for the first time in the literature. These findings indicate that humic acid can be used as an alternat...Continue Reading
References
Apr 1, 1990·Journal of Ethnopharmacology·R K GoelS B Acharya
Dec 1, 1995·Journal of Dental Research·T ZellesM G Humphreys-Beher
Sep 2, 1999·The New England Journal of Medicine·A J Singer, R A Clark
Nov 4, 2000·The Journal of Antimicrobial Chemotherapy·C E van RensburgJ Dekker
Apr 9, 2001·Clinical Microbiology Reviews·P G BowlerD G Armstrong
Nov 6, 2004·Inflammation·Gisela Käthe Jooné, Constance Elizabeth Jansen van Rensburg
Feb 21, 2007·Journal of Clinical Periodontology·Avital KozlovskyLiat Reich
May 15, 1981·Science·R Hartenstein
Dec 6, 2008·The Journal of Veterinary Medical Science·Hiroshi KodamaSaeko Ishida
Jan 5, 2010·Inflammopharmacology·P J W NaudéConstance E Jansen van Rensburg
Jan 14, 2011·International Journal of Dental Hygiene·H M HammadM S Khalifeh
Jul 7, 2011·Journal of Indian Society of Periodontology·M ShanmugamS Jai Karthik
Sep 26, 2013·BMC Oral Health·Leighann SherryGordon Ramage
Jul 6, 2014·International Journal of Molecular Medicine·Tingting ZhuHyeong-Cheol Yang
Nov 9, 2015·Journal of Periodontal Research·M ÇalışırZ Çınar
Mar 10, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Bruna Alice Gomes de MeloMaria Helena Andrade Santana
Mar 24, 2016·Acta Pharmaceutica Sinica. B·Yuanyuan JiZhidong Wang