PMID: 6022232May 12, 1967Paper

Humoral agent from calf lung producing pulmonary arterial vasoconstriction

Science
E D RobinH V Murdaugh

Abstract

Saline washings obtained in vivo from the lung of young calves produce pulmonary hypertension upon intrayascular (systemic or pulmonary) injection into either the dog or the calf. This pulmonary hypertension is produced by vasoconstriction of small, precapillary pulmonary vessels. The active agent, pulmonary arterial constrictor substance, differs chemically and physiologically from other substances which have been investigated with respect to vasomotor activity in the pulmonary circulation. Although the chemical nature of the active agent is not known it appears to have a relatively large molecular weight. Whether this agent plays a role in the physiological regulation of the pulmonary circulation is not known.

References

May 1, 1965·Journal of Applied Physiology·T C Lloyd
Jan 1, 1961·Physiological Reviews·A P FISHMAN
Aug 1, 1963·The Journal of Clinical Investigation·E H BERGOFSKYA P FISHMAN
Nov 1, 1963·The Journal of Surgical Research·D F HALMAGYIG J HORNER
Jul 1, 1949·Journal of Applied Physiology·H K HELLEMSL DEXTER

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Citations

May 2, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·H RemboldG Hennings
Dec 12, 1968·The New England Journal of Medicine·S I Said
May 1, 1968·Acta Physiologica Scandinavica·K Haavik-Nilsen, A Hauge
Jan 1, 1971·Chest·R M HarveyM I Ferrer
Jan 1, 1978·Microvascular Research·J L BenumofE A Wahrenbrock
Oct 1, 1967·Circulation Research·T BayleyA J Osbahr
Dec 23, 2011·Physiological Research·H MaxováM Vízek

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