PMID: 6985646Jan 1, 1980Paper

Humoral and cell-mediated immune responses in fully allogeneic bone marrow chimera in mice

The Journal of Experimental Medicine
K OnoéR A Good

Abstract

AKR mice were protected from lethal irradiation and established as long-lived chimeras by transplanting allogeneic C57BL/6 (B6) bone marrow that had been treated in vitro with anti-Thy-1 antiserum without complement. In these chimeras, which were designated [B6 {arrow} AKR], virtually all the thymus and spleen cells were shown to be derived from the B6 donor; several immune functions studied in these chimeras were as follows: (a) The chimeric mice were tolerant of histocompatibility antigens of both donor and recipient strain and nearly fully reactive to antigens of third party, as revealed by Simonsen's splenomegaly assay. The tolerance of these chimeras could not be attributed to suppressor cells but was compatible with clonal depletion. (b) Proliferative responses to concanavalin A, phytohemagglutinin, and lipopolysaccharide as well as natural killer and antibody-dependent cell- mediated cytotoxicity activity of the chimeric mice was normal. (c) Plaque- forming cell (PFC) assays of antibody responses to sheep erythrocytes (SRBC) showed gross deficiency in the primary response of the [B6 {arrow} AKR] and [AKR {arrow} B6] chimeras. By contrast, [B6-H-2(k)(E(k)) {arrow} AKR] H-2-compatible chimeras and [AKR {arrow} AKR] syngene...Continue Reading

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·Y ReisnerN Sharon
Oct 1, 1975·The Journal of Experimental Medicine·H von BoehmerJ Sprent
Jan 1, 1977·Cold Spring Harbor Symposia on Quantitative Biology·H N ClamanJ W Moorhead
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Feb 1, 1979·The Journal of Experimental Medicine·R HongD D Manning
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G FernandesR A Good
Jul 21, 1977·Nature·L KlareskogP A Peterson
Sep 1, 1978·Archives of Dermatology·N Hunziker, R K Winkelmann
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·R B HerbermanD H Lavrin
Nov 1, 1975·The Journal of Experimental Medicine·R D Stout, L A Herzenberg
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J F MillerJ Gamble

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Citations

Jan 1, 1991·International Journal of Immunopharmacology·H YoshiiS Kishimoto
Oct 28, 1986·Biochimica Et Biophysica Acta·C L Reading, Y Takaue
Mar 27, 2001·Transplantation Proceedings·G CiancioJ Miller
Jun 1, 1987·Journal of Helminthology·K Sugane, T Matsuura
Feb 18, 1982·The New England Journal of Medicine·R A Good
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P J Fink, M J Bevan
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M NoguchiK Morikawa
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S IkeharaY Hamashima
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Himeno, R A Good
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·K IwabuchiK Onoé
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N FukushiK Onoé
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·E IshiiR A Good
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H AraseK Onoé
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·N S el Badri, R A Good
May 17, 2008·Avian Pathology : Journal of the W.V.P.A·M MukamotoT Baba
Jul 1, 1985·The Journal of Experimental Medicine·A N TheofilopoulosF J Dixon
Jan 1, 1991·The Journal of Experimental Medicine·K MatsumotoK Nomoto
Jan 1, 1994·Microbiology and Immunology·P P WambuaR A Good
Oct 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B Y WangR A Good
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·R M Zinkernagel, A Althage
Jan 1, 1986·Critical Reviews in Oncology/hematology·C A Sieff

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