Humoral and cell-mediated immune status in mice exposed to chloral hydrate

Environmental Health Perspectives
B M KauffmannA E Munson

Abstract

Chloral hydrate has been found in our drinking water supplies at levels up to 5 micrograms/1. The purpose of this study was to evaluate the functional status of the immune system in random-bred CD-1 mice exposed to chloral hydrate for 14 and 90 days. Male mice, following 14 or 90 days of exposure to 1/10 and 1/100 the actual oral LD50, exhibited no alterations in either humoral or cell-mediated immunity. However, female mice exposed for 90 days to chloral hydrate in the drinking water demonstrated a significant depression in humoral immune function. This depression was observed when spleen cells from exposed mice were evaluated for their ability to produce antibody against sheep erythrocytes. These females did not demonstrate any changes in cell-mediated immune status.

References

Jan 1, 1977·Journal of Toxicology and Environmental Health·E M WatersJ E Huff
Mar 15, 1982·Toxicology and Applied Pharmacology·V M SandersA E Munson
Apr 1, 1982·Environmental Health Perspectives·V M SandersA E Munson

❮ Previous
Next ❯

Citations

May 30, 2009·Environmental Health Perspectives·Glinda S CooperJennifer Jinot
Apr 1, 1982·Environmental Health Perspectives·V M SandersA E Munson
Sep 30, 1999·Environmental Health Perspectives·M D Mayes
May 12, 2000·Environmental Health Perspectives·H A Barton, H J Clewell
Oct 30, 2008·Journal of Immunotoxicology·Guillaume RavelJacques Descotes
Aug 31, 2006·International Journal of Toxicology·Michael R WoolhiserJohn M Waechter
Jun 17, 1998·Arthritis and Rheumatism·P J NietertM Dosemeci
Aug 23, 2017·Immunopharmacology and Immunotoxicology·Josue D OrdazJoseph M K Irudayaraj
Sep 5, 2002·Journal of Applied Toxicology : JAT·R PoonV E Valli
Feb 17, 2001·Journal of Applied Toxicology : JAT·R PoonI Chu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.