PMID: 6978671Jan 1, 1982Paper

Humoral and cell-mediated immunity in peripheral blood following introduction of antigen into the middle ear

The Annals of Otology, Rhinology, and Laryngology
A F RyanA Catanzaro

Abstract

Serum levels of specific IgG and the sensitization of peripheral blood T-lymphocytes were measured in guinea pigs after single-dose antigenic sensitization by two routes: intratympanic and intradermal injection. Keyhole limpet hemocyanin (KLH) served as the antigen. Intratympanic injection of antigen resulted in much lower levels of circulating anti-KLH IgG than intradermal injection. When KLH was conjugated with alum to produce nonspecific inflammation and serve as adjuvant, the intratympanic route was considerably enhanced, but remained much less effective than the intradermal route. Development of an IgG response was also somewhat less rapid following intratympanic than following intradermal administration. Marked sensitization of circulating T-lymphocytes was seen after intradermal injection of alum-precipitated KLH. A much weaker, though still positive, response was seen after intradermal injection of KLH alone and with the intratympanic injection of alum-precipitated KLH. No T-lymphocyte sensitization could be detected after intratympanic injection of KLH alone. It was concluded that the afferent limb of both humoral (IgG) and cell-mediated immunity was operative in the middle ear. Therefore, the middle ear does not repre...Continue Reading

References

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Citations

Jul 1, 1997·Auris, Nasus, Larynx·S UeyamaG Mogi
Jan 1, 1988·Archives of Oto-rhino-laryngology·Y HamaguchiY Sakakura
Sep 1, 1988·American Journal of Otolaryngology·M SuzukiG Mogi
Jan 1, 1985·Auris, Nasus, Larynx·Y DakeT Tabata
Jul 7, 1999·Otolaryngologic Clinics of North America·T T Jung, J B Hanson
Mar 1, 1984·The Annals of Otology, Rhinology, and Laryngology·J P Harris
Jan 1, 1995·The Annals of Otology, Rhinology, and Laryngology·M Suzuki, J P Harris
Jul 1, 1989·The Annals of Otology, Rhinology, and Laryngology·Y HamaguchiY Sakakura
May 1, 1986·The Annals of Otology, Rhinology, and Laryngology·A F RyanJ P Harris
Jan 1, 1983·Acta Oto-laryngologica·A F Ryan, A Catanzaro
Jan 1, 1989·Acta Oto-laryngologica. Supplementum·T MorizonoS K Juhn
Mar 1, 1985·The Annals of Otology, Rhinology, and Laryngology·P BoisvertA F Ryan
Feb 1, 1983·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J P Harris
Mar 1, 1985·The Annals of Otology, Rhinology, and Laryngology·J P Harris, A F Ryan
Sep 1, 1986·Clinical Immunology and Immunopathology·A F RyanC W Vogel

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