PMID: 2504678Aug 1, 1989Paper

Humoral and cellular immune response in growing rats fed a 10% gluten diet

Israel Journal of Medical Sciences
R M Lotan

Abstract

The effect of protein malnutrition, induced by a diet containing 10% plant wheat gluten, on the immune response system was studied in growing rats. The rats were fed wheat gluten or casein (control) diets, and were the offspring of mothers fed a commercial stock rat diet, a gluten diet, or a casein diet during pregnancy and lactation. Rats fed dietary wheat gluten showed a depressed humoral immune response to antigenic stimulation with sheep red blood cells, regardless of the mother's diet. Both IgG and IgM antibody titers were depressed by the gluten diet, but the effect on IgG was more pronounced. Total hemolysin titers of gluten-fed rats were 41% that of the casein-fed rats. Hemolysin antibodies resistant to 2-mercaptoethanol appeared in the gluten-fed rats 5 days later than in the control rats, and their titers were 38% that of the controls. The number of spleen plaque-forming cells in the experimental rats at the peak of response was lower and delayed by 1 day. An impairment in the cellular immune response, measured by in vitro stimulation of lymphocytes with concanavalin A, was found in the gluten-fed rats. The amount of [3H]methylthymidine incorporated into newly synthesized DNA of lymphocytes taken from lymph nodes of r...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.