Humoral and Innate Antiviral Immunity as Tools to Clear Persistent HIV Infection

The Journal of Infectious Diseases
Guido FerrariBarton F Haynes

Abstract

Human immunodeficiency virus (HIV) type 1 uses the CD4 molecule as its principal receptor to infect T cells. HIV-1 integrates its viral genome into the host cell, leading to persistent infection wherein HIV-1 can remain transcriptionally silent in latently infected CD4+ T cells. On reactivation of replication-competent provirus, HIV-1 envelope glycoproteins (Env) are expressed and accumulate on the cell surface, allowing infected cells to be detected and targeted by endogenous immune responses or immune interventions. HIV-1 Env-specific antibodies have the potential to bind HIV-1 cell surface Env and promote elimination of infected CD4+ T cells by recruiting cytotoxic effector cells, such as natural killer cells, monocytes, and polymorphonuclear cells. Harnessing humoral and innate cellular responses has become one focus of research to develop innovative strategies to recruit and redirect cytotoxic effector cells to eliminate the HIV-1 latently infected CD4+ T-cell reservoir.

References

Apr 1, 1991·Trends in Biotechnology·R E Bird, B W Walker
May 3, 2002·Nature·Daniel C DouekRichard A Koup
Mar 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Douglas D RichmanChristos J Petropoulos
Mar 21, 2003·Nature·Xiping WeiGeorge M Shaw
Sep 15, 2004·The Journal of Experimental Medicine·Jason M BrenchleyDaniel C Douek
Dec 14, 2004·Nature·Photini KiepielaPhilip J R Goulder
Feb 3, 2005·International Journal of Cancer. Journal International Du Cancer·Patrick HoffmannPatrick A Baeuerle
Aug 19, 2006·Nature Medicine·Lydie TrautmannRafick-Pierre Sekaly
Dec 17, 2008·Nature·Vijayakumar VeluRama Rao Amara
Jan 7, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Adam C FinnefrockTong-Ming Fu
May 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel E Kaufmann, Bruce D Walker
Jun 3, 2009·The Journal of Experimental Medicine·Nilu GoonetillekeAndrew J McMichael
Oct 22, 2009·The New England Journal of Medicine·Supachai Rerks-NgarmUNKNOWN MOPH-TAVEG Investigators
Jan 6, 2010·Current Opinion in HIV and AIDS·Georgia D Tomaras, Barton F Haynes
Jan 21, 2011·PLoS Pathogens·Iliyana MikellLeonidas Stamatatos
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Amy W ChungIvan Stratov
Apr 29, 2011·Current Opinion in Immunology·Laurent VerkoczyBarton F Haynes
Apr 30, 2011·Blood·Christoph Rader
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dennis R BurtonJohn P Moore
Aug 5, 2011·Nature·Galit AlterMarcus Altfeld
Aug 19, 2011·Nature·Laura M WalkerPascal Poignard

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Citations

Jul 4, 2018·AIDS Research and Human Retroviruses·Will DampierBrian Wigdahl
Sep 7, 2017·Antimicrobial Agents and Chemotherapy·Edurne Garcia-VidalJosé A Esté
Nov 21, 2019·Vaccines·Patrick O'ConnellYasser A Aldhamen
Jul 3, 2020·Human Vaccines & Immunotherapeutics·Akshita Gupta, Yatender Kumar
Aug 1, 2020·Current Opinion in HIV and AIDS·Marina Tuyishime, Guido Ferrari
May 28, 2019·Cellular and Molecular Life Sciences : CMLS·Ivan Sadowski, Farhad B Hashemi
Nov 12, 2019·Frontiers in Cellular and Infection Microbiology·Clementine WalletChristian Schwartz
Aug 30, 2020·International Journal of Molecular Sciences·Huy NguyenVishwanath Venketaraman
Aug 2, 2017·Cell·Joshua A HorwitzMichel C Nussenzweig
Aug 30, 2019·Current Opinion in Systems Biology·Jessica M Conway, Ruy M Ribeiro

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