Humoral and mucosal immunity in protection from natural respiratory syncytial virus infection in adults

The Journal of Infectious Diseases
E E Walsh, A R Falsey

Abstract

Virus-specific nasal immunoglobulin (Ig) A and serum antibody titers in 67 respiratory syncytial virus (RSV)-infected adults were compared with titers in age-matched uninfected control subjects. Control subjects had significantly higher levels of nasal IgA and serum IgG to the RSV F, Ga, and Gb proteins than infected subjects. Serum neutralizing-antibody titers to group A and B RSV strains were also lower in infected subjects, although differences were not as large. Multivariate analysis found that low RSV-specific nasal IgA was an independently significant risk factor for RSV infection.

Citations

Apr 12, 2013·Clinical Reviews in Allergy & Immunology·Andrea T BorchersLaurel J Gershwin
Oct 29, 2010·The Journal of Infectious Diseases·F Eun-Hyung LeeEdward E Walsh
Feb 6, 2013·The Journal of Infectious Diseases·Edward E WalshAnn R Falsey
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Dec 28, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Xiaocong YuLisa Cavacini
Jul 26, 2005·Drugs & Aging·Ann R Falsey, Edward E Walsh
Feb 23, 2010·Aging Health·Ross B Fulton, Steven M Varga
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Dec 17, 2009·Vaccine·Ann R FalseyEdward E Walsh
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Feb 10, 2017·Clinical Microbiology Reviews·Clark D RussellJürgen Schwarze
Dec 3, 2016·Clinical Microbiology Reviews·Cameron GriffithsDavid J Marchant

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