Humoral hypercalcemia of hepatocellular carcinoma associated with elevated levels of parathyroid-hormone-related-peptide.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
K K Pun, S M Tam

Abstract

Parathyroid-hormone-related-peptide (PTHrP) has been shown to be important in the pathogenesis of hypercalcemia of malignancy. The malignancies most commonly associated with hypersecretion of PTHrP include squamous cell carcinoma and breast cancer. The pathogenesis of hypercalcemia associated with hepatocellular carcinoma was evaluated in this study. Two male patients with hepatocellular carcinoma were found to have severe hypercalcemia at initial presentation. PTHrP was measured with radioimmunoassay in these two patients before treatment as well as in nine other patients with hepatocellular carcinoma but without hypercalcemia. The levels were markedly elevated in the two patients with hypercalcemia (29.3 and 32.1 pM), but were less than 5 pM in the nine patients without hypercalcemia. These results suggest that PTHrP was important in the pathogenesis of hypercalcemia associated with hepatocellular carcinoma in these men.

References

Dec 1, 1990·The Journal of Clinical Endocrinology and Metabolism·A F Stewart, A E Broadus
Feb 1, 1990·Clinical Biochemistry·K W Ng, T J Martin
May 1, 1988·Journal of Endocrinological Investigation·K K PunR T Yeung
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J M MoseleyJ D Zajac
Aug 1, 1969·The American Journal of Medicine·A J McFadzean, R T Yeung
Sep 1, 1972·Medicine·S Margolis, C Homcy
Nov 1, 1981·The Journal of Clinical Endocrinology and Metabolism·D GoltzmanA E Broadus
May 31, 1965·JAMA : the Journal of the American Medical Association·R T KELLERF W LAFFERTY

❮ Previous
Next ❯

Citations

Apr 13, 2007·Digestive Diseases and Sciences·Pere TudelaEugeni Domènech
Sep 8, 2011·Current Opinion in Endocrinology, Diabetes, and Obesity·Gregory A Clines
Jun 15, 2006·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Eric J MahoneyRonald De Lellis

❮ Previous
Next ❯

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.