Humoral immune failure defined by immunoglobulin class and immunoglobulin G subclass deficiency is associated with shorter treatment-free and overall survival in Chronic Lymphocytic Leukaemia

British Journal of Haematology
Kyle CrassiniStephen P Mulligan

Abstract

Immune dysfunction attributed to hypogammaglobulinaemia is common in chronic lymphocytic leukaemia (CLL) and infection is a major contributor to morbidity and mortality. A higher incidence of multiple immunoglobulin and immunoglobulin G (IgG) subclass deficiency was associated with more advanced disease (P < 0·001 and P < 0·001, respectively) in a cohort of 147 CLL patients. Multiple immunoglobulin and IgG subclass deficiency were significantly associated with shorter treatment-free survival (TFS) (P < 0·001 and P = 0·006, respectively). The association between disease stage and immune dysfunction demonstrated by these data suggest aspects of immune deficiency correlate with disease severity and may be associated with shorter TFS in CLL.

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Citations

Jun 12, 2020·Immunological Investigations·Cecilia NapodanoUmberto Basile
Jan 19, 2020·Nature Communications·Rudi AgiusCarsten U Niemann
Jul 28, 2020·British Journal of Haematology·Andrea CorbingiLuca Laurenti
Nov 20, 2020·European Journal of Haematology·Vilhjálmur SteingrímssonSigurdur Y Kristinsson
Sep 23, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shanmugapriya ThangavadivelFarrukh T Awan
Jan 19, 2021·Asia-Pacific Journal of Clinical Oncology·Tanja M WindeggerYoke-Lin Fung
Dec 15, 2020·Frontiers in Immunology·Valentina GriggioMarta Coscia
Dec 6, 2019·International Archives of Allergy and Immunology·Xinyu TianYue Wang

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