Humoral immune reaction of newborn calves congenitally infected with Neospora caninum and experimentally treated with toltrazuril.

Parasitology Research
Corinne HaerdiB Gottstein

Abstract

Neospora caninum is widely recognized as one of the most important infectious organisms causing abortion and stillbirth in cattle. This parasite causes severe economical losses worldwide. Infection is mostly passed vertically from mother to calf during pregnancy. Under certain circumstances, an infection can lead to abortion, but in most cases it results in a chronically infected calf, which itself will represent the next endogenously infectious generation. So far, no reliable therapeutic or metaphylactic tool has been developed. One possibility to control the problem may consist of treating newborn calves that became vertically infected by a persistently infected mother. This may allow parasite-free offspring. The aim of the present study was to address the questions: (1) can serology be used to assess efficiency of treatment in toltrazuril-medicated animals? and (2) is a strategic prevention measure possible by means of producing N. caninum-free calves from positive cows? Calves from Neospora-seropositive cows and heifers were randomly split into two different medication groups: 36 calves were medicated with toltrazuril and 36 calves obtained a placebo. Medication (20 mg toltrazuril per kg bw) was administered three times, ev...Continue Reading

References

Dec 2, 1996·Veterinary Parasitology·J P Dubey, D S Lindsay
Nov 4, 2000·Journal of the American Veterinary Medical Association·K S BarlingL G Adams
Nov 9, 2000·Parasitology Research·G Greif
Sep 11, 2001·Journal of the American Veterinary Medical Association·J HernandezA Donovan
Dec 26, 2001·Veterinary Parasitology·Jong-Tai KimHee-Jeong Youn
May 22, 2002·The Veterinary Record·M Hässig, B Gottstein
Nov 20, 2002·Annals of Clinical Microbiology and Antimicrobials·Sandra KritznerBruno Gottstein
Dec 11, 2002·Trends in Parasitology·Elisabeth A InnesPatricia A Conrad
Dec 24, 2002·Journal of the American Veterinary Medical Association·Jorge HernandezArthur Donovan
Apr 2, 2003·The Korean Journal of Parasitology·J P Dubey, John Dubey
Feb 14, 2004·Parasitology Research·Anne Kathrin DariusAlfred Otto Heydorn
Jul 21, 2004·Veterinary Parasitology·C M OkeomaL Gillespie
Jun 2, 2005·The Journal of Eukaryotic Microbiology·Sheila M MitchellDavid S Lindsay

❮ Previous
Next ❯

Citations

Feb 12, 2009·Parasitology Research·M StrohbuschB Gottstein
Apr 13, 2007·Clinical Microbiology Reviews·J P DubeyL M Ortega-Mora
Mar 1, 2012·Veterinary Parasitology·Jun HiasaYoshifumi Nishikawa
May 6, 2020·Scientific Reports·Luiz Miguel PereiraAna Patrícia Yatsuda
Aug 24, 2017·Journal of Veterinary Pharmacology and Therapeutics·M L StockW H Hsu
Mar 5, 2018·International Journal for Parasitology. Drugs and Drug Resistance·Roberto Sánchez-SánchezLuis Miguel Ortega-Mora

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.