PMID: 9657263Jul 10, 1998Paper

Humoral immune response to a 200-kDa glycoprotein antigen of Saccharomyces cerevisiae is common in man

Immunology Letters
U SanderG Kunze

Abstract

According to Heelan et al. patients suffering from Crohn's disease (CD) produce antibodies against a cell wall associated glycoprotein antigen gp200 of the yeast Saccharomyces cerevisiae, while healthy people do not. Here the authors show, that antibodies against this glycoprotein gp200 can also be detected in the sera of healthy humans. The intensity of the antibody titer which is measured by immunoblot experiments is independent from the state of health. The Saccharomyces cerevisiae specific gp200 is a highly glycosylated protein localized not only in the cell wall but also accumulated in the culture medium. Some of the tested sera from CD patients, as well as from healthy adults, also reacted with a 120-kDa glycoprotein which is to be found in preparations containing secreted proteins. Because the binding of antibodies is greatly reduced by periodate treatment of gp200 and by the 120-kDa polypeptide, it is very likely that their carbohydrate moieties are the antigenic determinants against which the specific human antibodies are directed. The human humoral immune response applies only to Saccharomyces cerevisiae antigens, because no analogous immune responses could be detected against antigens derived from the yeast Arxula ad...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 1, 1991·Immunology Letters·B T HeelanR M Barnes
Jan 1, 1990·International Archives of Allergy and Applied Immunology·R M BarnesP M Johnson
Oct 29, 1988·BMJ : British Medical Journal·J MainD Parratt
Mar 1, 1996·Applied Microbiology and Biotechnology·D M BuiG Kunze

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Citations

Nov 3, 2006·Diseases of the Colon and Rectum·Chang Hwan ChoiHyon Suk Kim
Oct 23, 2002·Alimentary Pharmacology & Therapeutics·J Van Den BogaerdeM A Kamm
Dec 14, 2002·Inflammatory Bowel Diseases·Khalid KhanSally Weisdorf-Schindele
Feb 13, 2003·The Journal of Pathology·Nobuhide OshitaniTetsuo Arakawa
Oct 17, 2003·World Journal of Gastroenterology : WJG·Zsolt BartaGyula Szegedi

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