Humoral immune response to primary rubella virus infection

Clinical and Vaccine Immunology : CVI
Kim M WilsonElizabeth M Dax

Abstract

An assay capable of distinguishing between the immune response generated by recent exposure to rubella virus and the immune response existing as a result of past exposure or immunization is required for the diagnosis of primary rubella virus infection, especially in pregnant women. Avidity assays, which are based on the premise that chaotropic agents can be used to selectively dissociate the low-avidity antibodies generated early in the course of infection, have become routinely used in an effort to accomplish this. We have thoroughly investigated the immunological basis of an avidity assay using a viral lysate-based assay and an enzyme-linked immunosorbent assay (ELISA) based on a peptide analogue of the putative immunodominant region of the E1 glycoprotein (E1208-239). The relative affinities of the antibodies directed against E1208-239 were measured by surface plasmon resonance and were found to correlate well with the avidity index calculated from the ELISA results. We found that the immune response generated during primary rubella virus infection consists of an initial low-affinity peak of immunoglobulin M (IgM) reactivity followed by transient peaks of low-avidity IgG3 and IgA reactivity. The predominant response is an Ig...Continue Reading

References

Sep 1, 1992·Journal of Virological Methods·H I ThomasJ M Best
Feb 1, 1991·Journal of Virological Methods·H I Thomas, P Morgan-Capner
Mar 1, 1985·Scandinavian Journal of Immunology·A SarnestoO Mäkelä
Feb 1, 1996·Clinical and Experimental Immunology·H I ThomasP Morgan-Capner
May 26, 1999·Australian and New Zealand Journal of Medicine·V SintchenkoG L Gilbert
Oct 12, 2000·Clinical Microbiology Reviews·J Y Lee, D S Bowden
Jun 22, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·J NedeljkovicC Oker-Blom
Aug 29, 2001·Pathology·D E DwyerUNKNOWN Board of Education of the Royal College of Pathologists of Australasia
Feb 28, 2002·Annual Review of Immunology·Tasuku HonjoMasamichi Muramatsu
May 10, 2002·The Medical Journal of Australia·Gwendolyn L Gilbert
Jul 20, 2002·BMJ : British Medical Journal·Jennifer M BestGisela Enders
Jul 9, 2004·Academic Medicine : Journal of the Association of American Medical Colleges·Robert E BeachJames S Goodwin

❮ Previous
Next ❯

Citations

Dec 21, 2012·Clinical and Vaccine Immunology : CVI·Wayne DimechKim Wilson
Oct 15, 2009·Future Microbiology·Roderick J ChappelElizabeth M Dax
May 8, 2015·Journal of Medical Virology·Seyed Mahmood Seyed KhorramiNazanin Zahra Shafiei Jandaghi
Oct 2, 2007·Dermatologic Clinics·Eleonora RuoccoMaria Antonietta Tufano
Dec 13, 2007·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
May 18, 2007·Journal of Clinical Laboratory Analysis·C T PercianiM M Tanizaki
Jan 13, 2015·Lancet·Nathaniel LambertGregory A Poland
Nov 27, 2015·Clinical Microbiology Reviews·Wayne DimechChristelle Vauloup-Fellous
May 14, 2016·Journal of Clinical Microbiology·Wayne Dimech
Jun 8, 2017·Memórias do Instituto Oswaldo Cruz·Priscila T BaschirottoLeonardo Foti
Dec 15, 2008·Sensors·Chris Rowe TaittFrances S Ligler
Feb 9, 2021·Frontiers in Immunology·Flora PeyvandiIsabella Garagiola
Feb 4, 2019·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·O PiconeC Vauloup-Fellous

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.