Humoral Immune Response to SARS-CoV-2 in Iceland

The New England Journal of Medicine
Daniel F GudbjartssonKari Stefansson

Abstract

Little is known about the nature and durability of the humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We measured antibodies in serum samples from 30,576 persons in Iceland, using six assays (including two pan-immunoglobulin [pan-Ig] assays), and we determined that the appropriate measure of seropositivity was a positive result with both pan-Ig assays. We tested 2102 samples collected from 1237 persons up to 4 months after diagnosis by a quantitative polymerase-chain-reaction (qPCR) assay. We measured antibodies in 4222 quarantined persons who had been exposed to SARS-CoV-2 and in 23,452 persons not known to have been exposed. Of the 1797 persons who had recovered from SARS-CoV-2 infection, 1107 of the 1215 who were tested (91.1%) were seropositive; antiviral antibody titers assayed by two pan-Ig assays increased during 2 months after diagnosis by qPCR and remained on a plateau for the remainder of the study. Of quarantined persons, 2.3% were seropositive; of those with unknown exposure, 0.3% were positive. We estimate that 0.9% of Icelanders were infected with SARS-CoV-2 and that the infection was fatal in 0.3%. We also estimate that 56% of all SARS-CoV-2 infections in I...Continue Reading

References

Sep 26, 2007·Immunity·Thomas Dörner, Andreas Radbruch
Mar 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juanjuan ZhaoZheng Zhang
Apr 3, 2020·The Lancet Infectious Diseases·Robert VerityNeil M Ferguson
Apr 10, 2020·The European Respiratory Journal·Janice M LeungDon D Sin
Apr 15, 2020·The New England Journal of Medicine·Daniel F GudbjartssonKari Stefansson
Jun 3, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Kathleen G BeavisVera Tesic
Jun 9, 2020·Immunity·Nicolas VabretUNKNOWN Sinai Immunology Review Project
Jun 20, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
Jun 21, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·A J JääskeläinenM Lappalainen
Jul 1, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·B MeyerUNKNOWN Geneva Center for Emerging Viral Diseases
Jul 8, 2020·Nature Communications·Corine H GeurtsvanKesselMarion Koopmans
Jul 18, 2020·The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine·Sally H AdamsCharles E Irwin

❮ Previous
Next ❯

Citations

Sep 2, 2020·The New England Journal of Medicine·Galit Alter, Robert Seder
Sep 19, 2020·The Medical Journal of Australia·Nicolette R HoltAllen C Cheng
Oct 7, 2020·Journal of Clinical Medicine·Margherita BruniFederica Facciotti
Oct 8, 2020·Nature Reviews. Immunology·Marc LipsitchShane Crotty
Oct 18, 2020·Nature Reviews. Microbiology·Shan SuShibo Jiang
Oct 21, 2020·Nature Reviews. Nephrology·Luca PericoGiuseppe Remuzzi
Oct 27, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ferric C FangRobert T Schooley
Oct 13, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marlies MulderMarjolijn C A Wegdam-Blans
Nov 11, 2020·Biochemical Society Transactions·Jiayue-Clara Jiang, Yan Zhang
Nov 3, 2020·Journal of Medical Virology·Chuanmiao LiuXinxin Zhang
Nov 13, 2020·Viral Immunology·Martin KrsakCarlos Franco-Paredes
Nov 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pedro Martínez-FletaMar Valés-Gómez
Nov 27, 2020·Nature·Megan Scudellari
Nov 5, 2020·Environmental Microbiology·Harald Brüssow
Nov 28, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Claudia Santos-HövenerThomas Lampert
Dec 4, 2020·The New England Journal of Medicine·Alicia T WidgeUNKNOWN mRNA-1273 Study Group
Dec 4, 2020·Human Vaccines & Immunotherapeutics·Vipin M Vashishtha, Puneet Kumar
Dec 15, 2020·Wiener klinische Wochenschrift·Florian DeisenhammerMarkus Reindl
Dec 19, 2020·Frontiers in Microbiology·Tanveer AhmadSyed Mansoor Ali
Nov 6, 2020·Transplantation·Yorg AzziEnver Akalin
Dec 2, 2020·European Journal of Immunology·François AnnaOlivier Lantz
Jan 1, 2021·PloS One·Nathan PostSharif A Ismail
Dec 29, 2020·Environmental Microbiology·Harald Brüssow
Dec 29, 2020·Journal of Medical Virology·Patricia BustosEugenio Ramírez
Jan 5, 2021·Frontiers in Immunology·Yannick GalipeauMarc-André Langlois
Jan 4, 2021·Diagnostic Microbiology and Infectious Disease·Ruggero DittadiPaolo Carraro
Nov 23, 2020·The Lancet Infectious Diseases·Cathal RoartyUNKNOWN Covid Warriors research team
Dec 15, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Yujie BaoYing Wang
Nov 4, 2020·Journal of Clinical Microbiology·Andrew CameronNicole D Pecora
Jan 15, 2021·Nature Medicine·Petter Brodin
Dec 12, 2020·Clinical Medicine : Journal of the Royal College of Physicians of London·Jack WestNikitas Nikitas
Dec 21, 2020·The Lancet Infectious Diseases·Els DuysburghIsabelle Desombere
Jan 27, 2021·Cell·Alessandro Sette, Shane Crotty
Jan 23, 2021·Advanced Drug Delivery Reviews·Saborni ChakrabortyTaia T Wang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.