Humoral immune responses in hospitalized COVID-19 patients.

Saudi Journal of Biological Sciences
Waleed Mahallawi

Abstract

The emerging coronavirus 2019 (COVID-19) disease, caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a worldwide public health crisis. Antibody analysis is an important procedure for the diagnosis of COVID-19 patients. We investigated the IgG, IgM, and IgA responses against the SARS-CoV-2 spike (S) protein among hospitalized COVID-19 patients. Hospitalized COVID-19 patients (n = 178) in the Al Madinah region, Saudi Arabia, participated in this study. Of the 178 patients, 72 (40%) were categorized as severe, including 50 (69%) males and 22 (31%) females. The remaining106 (60%) patients were categorized as non-severe, including 85 (80%) males and 21 (20%) females. Qualitative reverse transcription-polymerase chain reaction (RT-PCR) to detect the presence of SARS-CoV-2 RNA was used to confirm the diagnosis of each patient. The specific anti-SARS-CoV-2 S protein IgG, IgM, and IgA antibodies in patients' sera were measured using enzyme-linked immunosorbent assay (ELISA) and compared between case presentations. The current study showed that all severe hospitalized patients presented significantly (p < 0.0001) increased anti-S IgG and IgM antibody accumulation compared with non-severe patients. A...Continue Reading

References

Feb 20, 2020·The New England Journal of Medicine·Lirong ZouJie Wu
Mar 7, 2020·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Anne K Cordes, Albert Heim
Mar 15, 2020·The Lancet. Respiratory Medicine·Hua Cai
Mar 18, 2020·Travel Medicine and Infectious Disease·Alfonso J Rodriguez-MoralesUNKNOWN Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19). Electronic address: https://www.lancovid
Mar 30, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Juanjuan ZhaoZheng Zhang
Apr 2, 2020·Viruses·Yuefei JinGuangcai Duan
Apr 29, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Andrea PadoanMario Plebani
May 1, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
May 3, 2020·Emerging Microbes & Infections·Baoqing SunLing Chen
May 14, 2020·The European Respiratory Journal·Hai-Qiong YuNan-Shan Zhong
May 14, 2020·Nature Medicine·Fatima AmanatFlorian Krammer
May 24, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Jun WuXiangyou Li
Jun 10, 2020·Journal of Clinical Medicine·Alberto M Borobia On Behalf Of The Covid Hulp Working Group
Jun 10, 2020·Intensive Care Medicine·Shadman AzizMichael D Christian
Jun 15, 2020·Journal of Infection and Public Health·Jitendra Prasad Mathuria Rajkumar
Jun 20, 2020·Nature Medicine·Quan-Xin LongAi-Long Huang
Jun 20, 2020·Journal of the Pediatric Infectious Diseases Society·William R OttoJeffrey S Gerber
Jul 1, 2020·Journal of Medical Virology·Anding LiuDong Xu
Jul 15, 2020·The New England Journal of Medicine·Penny M Heaton
Aug 4, 2020·MedRxiv : the Preprint Server for Health Sciences·Anita S IyerRichelle C Charles
Sep 23, 2020·Science Translational Medicine·Carl A PierceBetsy C Herold
Dec 9, 2020·Science Translational Medicine·Delphine SterlinGuy Gorochov
Jan 12, 2021·Journal of Taibah University Medical Sciences·Waleed H Mahallawi
Feb 2, 2021·Saudi Journal of Biological Sciences·Waleed H Mahallawi, Abdulmohsen H Al-Zalabani

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.