Humoral immunity 10 years after booster immunization with an adolescent and adult formulation combined tetanus, diphtheria, and 5-component acellular pertussis vaccine

Vaccine
A TomoviciP Lavigne

Abstract

Persistence of antibodies after a single dose of Tdap vaccine (tetanus, diphtheria, and 5-component acellular pertussis vaccine) was evaluated in a follow-up study of adolescents (N=324) and adults (N=644) who had received Tdap in earlier clinical trials. Outcome measures were seroprotection (tetanus and diphtheria) or seropositivity (pertussis) and geometric mean concentrations. Humoral immune responses to all antigens were robust 1 month after initial immunization, decreased at subsequent measurements, but continued to exceed pre-immunization levels 1, 3, 5, and 10 years later. Protective levels of diphtheria and tetanus antitoxin persisted in 99.3% of adolescents 10 years after a booster dose of Tdap. Seropositivity to 1 or more pertussis antigens also persisted in most adolescents for 10 years. Although tetanus antitoxin responses were similar in adults to those observed in adolescents, diphtheria antitoxin titers were lower, reflecting the fact that a smaller proportion of adults had received diphtheria toxoid in the previous 10 years compared to adolescents. These data will contribute to the selection of the optimal interval for repeat doses of Tdap.

References

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Citations

Dec 19, 2013·PloS One·Birgit WeinbergerBeatrix Grubeck-Loebenstein
May 9, 2013·Current Opinion in Pediatrics·Tali CapuaJoseph A Bocchini
Dec 20, 2012·Expert Review of Vaccines·Romina Libster, Kathryn M Edwards
Nov 7, 2015·Paediatric Drugs·Abdulbaset M SalimPaul E Kilgore
Jul 4, 2012·Vaccine·Timothy R PetersKatherine A Poehling
Mar 18, 2015·Vaccine·Kathi WaltherUlrich Heininger
Apr 15, 2016·Journal of Medical Microbiology·Raffaella Palazzo Sero-Epidemiology Working Group
Jan 4, 2017·Human Vaccines & Immunotherapeutics·Zhiyun Chen, Qiushui He
May 2, 2018·Expert Review of Vaccines·Paul LoubetOdile Launay
Oct 28, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eleonora BrilloErsilia Buonomo
Jul 12, 2013·Cadernos de saúde pública·José Cassio de MoraesLucia Ferro Bricks
Apr 28, 2018·MMWR. Recommendations and Reports : Morbidity and Mortality Weekly Report. Recommendations and Reports·Jennifer L LiangThomas A Clark
Jan 9, 2018·Annals of Medicine·Ivo VojtekAndrew Vyse
Feb 9, 2017·Clinical and Experimental Vaccine Research·Hyo-Jin Lee, Jung-Hyun Choi
May 21, 2021·Emerging Infectious Diseases·Longhuan MaEric T Harvill
Apr 1, 2016·Clinical Microbiology Reviews·Paul E KilgoreHeinz-Josef Schmitt
Jan 7, 2015·Pediatrics·Ashleigh McGirr, David N Fisman
May 13, 2015·Pediatrics·Kevin ForsythCarl Heinz Wirsing von König

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