Humoral immunity due to long-lived plasma cells

Immunity
Mark K SlifkaRafi Ahmed

Abstract

Conventional models suggest that long-term antibody responses are maintained by the continuous differentiation of memory B cells into antibody-secreting plasma cells. This is based on the notion that plasma cells are short-lived and need to be continually replenished by memory B cells. We examined the issue of plasma cell longevity by following the persistence of LCMV-specific antibody and plasma cell numbers after in vivo depletion of memory B cells and by adoptive transfer of virus-specific plasma cells into naive mice. The results show that a substantial fraction of plasma cells can survive and continue to secrete antibody for extended periods of time (>1 year) in the absence of any detectable memory B cells. This study documents the existence of long-lived plasma cells and demonstrates a new mechanism by which humoral immunity is maintained.

References

Apr 1, 1992·Immunological Reviews·I C MacLennanG D Johnson
Jul 1, 1991·Transplantation·D M Shepherd, R J Noelle
Jan 1, 1990·International Immunology·P Vieira, K Rajewsky
Oct 1, 1990·Immunological Reviews·J G TewA K Szakal
Feb 1, 1986·European Journal of Immunology·T Hibi, H M Dosch
Feb 1, 1988·European Journal of Immunology·P Vieira, K Rajewsky
Oct 1, 1986·European Journal of Immunology·F HoM Khan
Jun 1, 1967·Journal of Cellular Physiology·T MakinodanC J Chadwick
Jun 23, 1994·Nature·L L LauR Ahmed
May 1, 1993·Trends in Microbiology·D Gray
Sep 1, 1994·Journal of Virology·L HylandC Coleclough
Jan 1, 1996·Annual Review of Immunology·R M ZinkernagelH Hengartner
Jun 1, 1996·Seminars in Immunology·G Kelsoe
Apr 1, 1996·Immunological Reviews·D GrayP Dullforce
Nov 29, 1996·Journal of Immunological Methods·M K Slifka, R Ahmed
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·E Paramithiotis, M D Cooper
Jun 1, 1997·Immunology Today·S Romagnani
Jul 10, 1997·Nature·R A ManzA Radbruch
Jun 1, 1964·American Journal of Public Health and the Nation's Health·S GOTTLIEBG EDSALL
Jul 1, 1965·The Journal of Experimental Medicine·J L FAHEY, S SELL
Jan 1, 1962·The Journal of Experimental Medicine·O MAKELA, G J NOSSAL
Jan 1, 1962·The Journal of Experimental Medicine·G J NOSSAL, O MAKELA

❮ Previous
Next ❯

Citations

Nov 11, 1999·European Journal of Immunology·C García De VinuesaI C MacLennan
Mar 10, 2001·European Journal of Immunology·M PihlgrenC A Siegrist
Dec 26, 2001·European Journal of Immunology·Jens WrammertTomas Leanderson
Mar 29, 2002·European Journal of Immunology·Rudolf A Manz, Andreas Radbruch
Apr 7, 2012·Cellular and Molecular Life Sciences : CMLS·Andreas Radbruch
Dec 5, 2008·Journal of Clinical Immunology·Jens WrammertRafi Ahmed
Apr 16, 2013·Current Allergy and Asthma Reports·Julia Eckl-Dorna, Verena Niederberger
Dec 3, 2010·Immunologic Research·David J DiLilloThomas F Tedder
Mar 14, 2012·Immunologic Research·Wei-Xiang SinKeh-Chuang Chin
Mar 25, 2004·Trends in Immunology·Hilmar LemkeHans Lange
Apr 17, 2004·Journal of Immunological Methods·Shane CrottyRafi Ahmed
Oct 25, 2003·Journal of Theoretical Biology·Sergei S PilyuginRustom Antia
Jun 20, 2002·Veterinary Immunology and Immunopathology·Otti BengtssonKjell-Olov Grönvik
May 24, 2003·Vaccine·Elisabetta TraggiaiAntonio Lanzavecchia
Mar 3, 2001·Current Opinion in Immunology·J Sprent, C D Surh
Jun 29, 2002·Current Opinion in Immunology·Rudolf A ManzAndreas Radbruch
Jun 29, 2002·Current Opinion in Immunology·Rolf M Zinkernagel
Jun 25, 1998·Current Opinion in Immunology·M K Slifka, R Ahmed
Apr 12, 2003·Microbes and Infection·Michael McHeyzer-WilliamsMichael Eisenbraun
Jun 29, 2001·Trends in Immunology·J G TewD Qin
Oct 25, 2011·Cellular & Molecular Immunology·Ende ZhaoWeiping Zou
Nov 26, 2008·Immunology and Cell Biology·Francesca Di Rosa
Dec 22, 2010·Immunology and Cell Biology·Katrin MoserRudolf A Manz
Jun 3, 2005·Nature·Christopher C GoodnowCarola G Vinuesa
Nov 3, 2010·Nature Immunology·Nadége PelletierMichael G McHeyzer-Williams
Nov 29, 2001·Nature Immunology·K L Calame
Feb 27, 2007·Nature Immunology·Zou XiangKenneth G C Smith
Jan 22, 2005·Nature Reviews. Immunology·Rustom AntiaRafi Ahmed
Mar 2, 2005·Nature Reviews. Immunology·Miriam Shapiro-Shelef, Kathryn Calame
Sep 16, 2006·Nature Reviews. Immunology·Andreas RadbruchFalk Hiepe
Feb 16, 2010·Nature Reviews. Immunology·Koji TokoyodaAndreas Radbruch
Mar 22, 2002·Nature Reviews. Immunology·David Gray
Jun 15, 2007·Nature Reviews. Microbiology·Stefan H E Kaufmann
Feb 4, 2010·Nature Reviews. Nephrology·Antoine DurrbachBernard Charpentier

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.