Humoral Immunity in Heart Failure

Cardiovascular & Hematological Disorders Drug Targets
Amrita Sarkar, Khadija Rafiq

Abstract

Cardiovascular Disease (CVD) is a class of diseases that involve disorders of heart and blood vessels, including hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, which finally lead to Heart Failure (HF). There are several treatments available all over the world, but still, CVD and heart failure became the number one problem causing death every year worldwide. Both experimental and clinical studies have shown a role for inflammation in the pathogenesis of heart failure. This seems related to an imbalance between pro-inflammatory and anti-inflammatory cytokines. Cardiac inflammation is a major pathophysiological mechanism operating in the failing heart, regardless of HF aetiology. Disturbances of the cellular and humoral immune system are frequently observed in heart failure. This review describes how B-cells play a specific role in the heart failure states. There is an urgent need to identify novel therapeutic targets and develop advanced therapeutic strategies to combat the syndrome of HF. Understanding and describing the elements of the humoral immunity function are essential and may suggest potential new treatment strategies.

References

Dec 1, 1996·The Journal of Experimental Medicine·S D WolfC A Janeway
Aug 3, 1999·The Journal of Clinical Investigation·S FrantzR A Kelly
Mar 20, 2002·The Journal of Clinical Investigation·Giuseppina CaligiuriGöran K Hansson
Feb 6, 2004·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Emma J BirksMagdi H Yacoub
Jul 5, 2006·Heart Failure Reviews·Arne YndestadPål Aukrust
Nov 26, 2008·Nature Reviews. Immunology·Gökhan S Hotamisligil, Ebru Erbay
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Janet M TorpyRichard M Glass
Feb 12, 2010·Annals of the New York Academy of Sciences·David J DiLilloThomas F Tedder
Sep 8, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tin KyawBan-Hock Toh
Oct 19, 2010·Molecular Immunology·Gaetano VitaleCarlo Pucillo
Jul 30, 2011·Journal of the American College of Cardiology·Jill Downing, Gary J Balady
Jan 10, 2012·Circulation Research·Ziya KayaHugo A Katus
Feb 15, 2012·Vascular Pharmacology·Padmapriya PonnuswamyAlain Tedgui
Jan 12, 2013·Science·Filip K Swirski, Matthias Nahrendorf
Mar 23, 2013·Methodist DeBakey Cardiovascular Journal·Andrea M Cordero-ReyesGuillermo Torre-Amione
Aug 13, 2013·International Journal of Cardiology·Xavier PalomerManuel Vázquez-Carrera
Mar 20, 2014·European Journal of Applied Physiology·Rian Q Landers-RamosSteven J Prior
Apr 20, 2014·International Journal of Endocrinology·J Fuentes-AntrásO Lorenzo
May 9, 2014·Circulation Research·Hafid Ait-OufellaAlain Tedgui
Dec 22, 2014·The Journal of Allergy and Clinical Immunology·Francesco AnnunziatoSergio Romagnani
Jan 24, 2015·Nature Reviews. Immunology·Slava EpelmanDouglas L Mann
Mar 31, 2015·Circulation Research·Douglas L Mann
Apr 11, 2017·Cardiovascular Research·Kazuhiko Nishida, Kinya Otsu
Jun 5, 2017·Archives of Medical Research·Luis Sánchez-TrujilloGuillermo Torre-Amione

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Citations

Sep 28, 2018·Frontiers in Cardiovascular Medicine·Amrita SarkarKhadija Rafiq
Mar 12, 2019·Cardiovascular & Hematological Disorders Drug Targets·Rahul Mittal, Rahul Dev Jayant
Jul 9, 2021·Journal of Veterinary Internal Medicine·Natalia DruzhaevaAleksandra Domanjko Petrič

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